Mouse anti-Human Creatine Kinase Monoclonal Antibody | anti-CKMT1A antibody

Mouse Anti Human Creatine Kinase, Mitochondrial 1A

Cat. Num. AAA140471

• Gene Names: CKM; CKMM; M-CK
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Purified from mouse ascitic fluids by protein-A affinity chromatography
• Synonyms: Creatine Kinase; Monoclonal Antibody; Mouse Anti Human Creatine Kinase; Mitochondrial 1A; CKMT1A Antibody; Mouse Anti Human; Creatine kinase mitochondrial 1A; creatine kinase mitochondrial 1 (ubiquitous); creatine kinase U-type mitochondrial; Acidic-type mitochondrial creatine kinase; Ubiquitous mitochondrial creatine kinase; CKMT1; U-MtCK; mia-CK; EC 2.7.3; EC 2.7.3.2; anti-CKMT1A antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Clone Number: PAT17A2AT
• Purity/Purification: Purified from mouse ascitic fluids by protein-A affinity chromatography
• Form/Format: 1mg/ml containing PBS, pH-7.4, 10% Glycerol and 0.02% Sodium Azide.; Sterile filtered colorless solution.
• Sequence Length: 381

• Applicable Applications for anti-CKMT1A antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity.
• Ig Subclass: Mouse IgG2b heavy chain and k light chain.
• Immunogen: Anti-human CKMT1A mAb, clone PAT17A2AT, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human CKMT1A protein 40-417 amino acids purified from E Coli.
• Preparation and Storage: Storage: For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.; Stability: 12 months at -20 degree C. 1 month at 4 degree C.

Related Product Information for anti-CKMT1A antibody

CKMT1A is in charge of the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. CKMT1A is a member of the creatine kinase isoenzyme family and exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase arises in two different oligomeric forms: dimers and octamers, unlike the exclusively dimeric cytosolic creatine kinase isoenzymes. Numerous malignant cancers with poor prognosis have displayed overexpression of ubiquitous mitochondrial creatine kinase which is linked to high energy turnover and inability to remove cancer cells through apoptosis.

Product Categories/Family for anti-CKMT1A antibody

Monoclonal Antibodies; Anti-Human Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 180588
• NCBI GeneID: 1158
• Molecular Weight: 43,101 Da
• NCBI Official Full Name: creatine kinase
• NCBI Official Synonym Full Names: creatine kinase, M-type
• NCBI Official Symbol: CKM
• NCBI Official Synonym Symbols: CKMM; M-CK
• NCBI Protein Information: creatine kinase M-type
• UniProt Protein Name: Creatine kinase M-type
• Protein Family: Creatine kinase
• UniProt Gene Name: CKM
• UniProt Synonym Gene Names: CKMM
• UniProt Entry Name: KCRM_HUMAN

Uniprot Description

CKM: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. Belongs to the ATP:guanido phosphotransferase family.

Protein type: Amino Acid Metabolism - arginine and proline; EC 2.7.3.2; Kinase, other

Chromosomal Location of Human Ortholog: 19q13.32

Cellular Component: cytosol

Molecular Function: creatine kinase activity; protein binding

Biological Process: creatine metabolic process