F-box/WD repeat-containing protein 11 (Fbxw11) Recombinant Protein | Fbxw11 recombinant protein

Recombinant Mouse F-box/WD repeat-containing protein 11 (Fbxw11)

Cat. Num. AAA1389644

• Gene Names: Fbxw11; HOS; BTRC2; BTRCP2; Fbxw1b; AA536858; 2310065A07Rik
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: F-box/WD repeat-containing protein 11 (Fbxw11); Recombinant Mouse F-box/WD repeat-containing protein 11 (Fbxw11); Fbxw11 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-542, Full length protein
• Sequence: MEPDSVIEDKTIELMCSVPRSLWLGCANLVESMCALSCLQSMPSVRCLQISNGTSSVIVSRKRPSEGNYQKEKDLCIKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAENILSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFKNRPTDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDDKIISGLRDNSIKIWDKSSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTYTYISR
• Sequence Length: 542

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Fbxw11 recombinant protein

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. This protein belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence
absence of two alternate exons.

NCBI and Uniprot Product Information

• NCBI GI #: 405778325
• NCBI GeneID: 103583
• NCBI Accession #: NP_001258276.1
• NCBI GenBank Nucleotide #: NM_001271347.1
• UniProt Accession #: Q5SRY7; Q3TGM9; Q3TLZ8; Q8BY90; Q8K022; Q923H0
• Molecular Weight: 58,394 Da
• NCBI Official Full Name: F-box/WD repeat-containing protein 11 isoform b
• NCBI Official Synonym Full Names: F-box and WD-40 domain protein 11
• NCBI Official Symbol: Fbxw11
• NCBI Official Synonym Symbols: HOS; BTRC2; BTRCP2; Fbxw1b; AA536858; 2310065A07Rik
• NCBI Protein Information: F-box/WD repeat-containing protein 11
• UniProt Protein Name: F-box/WD repeat-containing protein 11
• Protein Family: F-box/WD repeat-containing protein
• UniProt Gene Name: Fbxw11
• UniProt Synonym Gene Names: Btrcp2; Fbw1b; Fbxw1b; HOS

Uniprot Description

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. Is target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action.