Rabbit FBXW11 Polyclonal Antibody | anti-FBXW11 antibody

Anti-FBXW11 Antibody

Cat. Num. AAA417509

• Gene Names: FBXW11; Hos; BTRC2; FBW1B; Fbw11; BTRCP2; FBXW1B
• Reactivity: Human. Predicted: Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity purified
• Synonyms: FBXW11; Polyclonal Antibody; Anti-FBXW11 Antibody; anti-FBXW11 antibody

• Host: Rabbit
• Reactivity: Human. Predicted: Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Affinity purified
• Form/Format: Liquid
• Concentration: 100ug/100ul (varies by lot)
• Sequence Length: 4395

• Applicable Applications for anti-FBXW11 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: ELISA titer: 1:20,000-1:80,000; Immunohistochemistry: 1:100-1:500; Optimal dilutions/concentrations should be determined by the end user
• Storage Buffer: PBS, pH 7.4 with 0.02% sodium azide.
• Immunogen: Rabbit polyclonal FBXW11(1) antibody was raised against a recombinate human FBXW11 protein 335-524aa (BC026213).
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Testing Data

Related Product Information for anti-FBXW11 antibody

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. This gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008]

References

(1) Cui,W., Xiao,N., Xiao,H., et al. beta-TrCP-mediated IRAK1 degradation releases TAK1-TRAF6 from the membrane to the cytosol for TAK1-dependent NF-kappaB activation. Mol. Cell. Biol. 32 (19), 3990-4000 (2012)

NCBI and Uniprot Product Information

• NCBI GI #: 20070727
• NCBI GeneID: 23291
• Molecular Weight: 60,898 Da
• NCBI Official Full Name: Homo sapiens F-box and WD repeat domain containing 11, mRNA
• NCBI Official Synonym Full Names: F-box and WD repeat domain containing 11
• NCBI Official Symbol: FBXW11
• NCBI Official Synonym Symbols: Hos; BTRC2; FBW1B; Fbw11; BTRCP2; FBXW1B
• NCBI Protein Information: F-box/WD repeat-containing protein 11; F-box and WD repeats protein beta-TrCP2; F-box and WD-40 domain protein 11; F-box and WD-40 domain protein 1B; F-box protein Fbw1b; F-box/WD repeat-containing protein 1B; beta-transducin repeat-containing protein 2; homologous to Slimb protein
• UniProt Protein Name: F-box/WD repeat-containing protein 11
• Protein Family: F-box/WD repeat-containing protein
• UniProt Gene Name: FBXW11
• UniProt Entry Name: FBW1B_HUMAN

NCBI Description

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008]

Uniprot Description

FBW1B: a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex May participate in Wnt signaling. Three alternatively spliced isoforms have been described.

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 5q35.1

Cellular Component: centrosome; SCF ubiquitin ligase complex; nucleus; cytosol; ubiquitin ligase complex

Molecular Function: protein dimerization activity; protein binding; ubiquitin-protein ligase activity

Biological Process: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; proteasomal ubiquitin-dependent protein catabolic process; Wnt receptor signaling pathway; protein polyubiquitination; protein destabilization; positive regulation of proteolysis; positive regulation of transcription, DNA-dependent; rhythmic process; protein ubiquitination; negative regulation of NF-kappaB import into nucleus; positive regulation of circadian rhythm; protein amino acid dephosphorylation; mitotic cell cycle; negative regulation of transcription, DNA-dependent; G2/M transition of mitotic cell cycle