RNF20 cdna clone
RNF20 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). [provided by RefSeq, Feb 2012]
Uniprot Description
RNF20: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6. Interacts with p53/TP53 and WAC. Interacts with PAF1; the interaction mediates the association of the PAF1 and RNF20/40 complexes which is a prerequsite for recruitment of UBE2A/B. Belongs to the BRE1 family.
Protein type: Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.-; EC 6.3.2.19; Ligase
Chromosomal Location of Human Ortholog: 9q22
Cellular Component: nucleolus; nucleoplasm; nucleus; ubiquitin ligase complex
Molecular Function: histone binding; mRNA 3'-UTR binding; p53 binding; protein binding; transcription coactivator activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity
Biological Process: histone H2B ubiquitination; histone monoubiquitination; negative regulation of cell migration; positive regulation of transcription, DNA-dependent; protein polyubiquitination; regulation of mitotic cell cycle; regulation of transcription, DNA-dependent; ubiquitin-dependent protein catabolic process
Research Articles on RNF20
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Product Notes
The RNF20 rnf20 (Catalog #AAA1274394) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGTCAGGAA TTGGAAATAA AAGAGCAGCT GGAGAACCTG GCACCTCCAT GCCTCCTGAG AAGAAGGCAG CTGTTGAAGA TTCAGGGACC ACAGTGGAAA CAATTAAGCT AGGAGGTGTC TCTTCAACGG AGGAACTAGA CATTAGAACA CTGCAAACCA AAAATCGCAA GCTGGCAGAA ATGTTGGATC AGCGGCAGGC CATTGAAGAT GAACTTCGTG AGCACATTGA AAAACTGGAA CGACGACAGG CCACTGATGA TGCCTCACTA TTGATTGTCA ACCGATACTG GAGTCAGTTT GATGAAAACA TCCGTATCAT CCTTAAACGT TATGATCTGG AGCAGGGCTT GGGAGACCTA CTCACAGAAC GAAAAGCCCT TGTTGTGCCT GAACCAGAAC CAGACTCTGA TAGCAATCAG GAGCGTAAAG ATGACCGAGA GAGAGGGGAA GGGCAAGAGC CAGCTTTCTC TTTCCTTGCT ACTTTGGCCA GCAGTTCCAG TGAAGAGATG GAGTCTCAGC TGCAGGAACG TGTGGAGTCT TCCCGCCGAG CCGTGTCCCA GATTGTGACT GTTTATGATA AATTGCAAGA AAAAGTGGAG CTCTTATCCC GGAAGCTAAA CAGTGGAGAT AATCTGATAG TGGAGGAAGC AGTGCAGGAG CTGAACTCTT TCCTCGCACA GGAGAATATG AGGCTACAGG AATTGACAGA TCTTCTTCAG GAAAAGCATC GCACCATGTC TCAGGAGTTC TCCAAGTTGC AGAGTAAAGT GGAGACAGCC GAATCACGAG TGTCTGTCCT GGAGTCCATG ATTGATGACC TGCAGTGGGA TATTGACAAA ATTCGAAAGA GGGAACAGCG ACTCAACCGA CACTTAGCAG AAGTCCTAGA ACGGGTGAAT TCCAAAGGTT ATAAGGTGTA TGGAGCGGGG AGCAGTCTGT ATGGCGGCAC AATCACTATC AATGCTCGGA AGTTTGAGGA AATGAATGCA GAGCTTGAGG AGAACAAAGA GTTGGCTCAG AACCGTCTCT GTGAGCTGGA GAAACTTCGG CAAGACTTTG AGGAGGTCAC TACACAAAAT GAAAAGCTGA AGGTGGAATT GCGGAGTGCA GTGGAGCAAG TCGTTAAGGA AACTCCAGAA TATCGCTGCA TGCAGTCACA GTTCTCCGTC TTGTATAATG AGAGCCTACA GTTGAAAGCA CACTTGGATG AGGCTCGGAC CCTGCTTCAT GGCACCAGAG GAACCCACCA GCACCAGGTT GAGCTTATTG AGCGAGATGA GGTTAGTCTT CATAAGAAGC TGAGGACTGA AGTAATTCAG CTAGAAGATA CATTGGCCCA GGTCCGCAAG GAGTATGAAA TGCTGAGGAT AGAATTTGAG CAGACCCTTG CTGCCAATGA ACAAGCAGGC CCTATAAACA GGGAGATGCG CCACCTCATC AGTAGCCTCC AGAATCACAA TCACCAGCTG AAAGGGGAGG TCCTGAGATA TAAGCGGAAA TTGAGAGAAG CCCAGTCTGA CCTGAACAAG ACACGCCTGC GTAGTGGTAG TGCCCTCCTG CAGTCCCAGT CTAGTACTGA GGACCCGAAG GATGAGCCTG CGGAGCTAAA ACCAGATTCT GAGGACTTAT CCTCCCAGTC CTCAGCTTCA AAGGCATCTC AGGAGGATGC CAATGAAATC AAGTCTAAAC GGGATGAAGA AGAACGAGAA CGAGAAAGGA GGGAGAAGGA GAGGGAACGA GAAAGAGAAC GGGAGAAGGA GAAGGAGAGA GAACGAGAGA AGCAGAAGCT AAAAGAGTCA GAAAAAGAGA GAGATTCTGC TAAGGATAAA GAGAAAGGCA AACATGATGA TGGACGGAAA AAGGAAGCAG AAATTATCAA ACAATTGAAG ATTGAACTCA AGAAGGCACA GGAGAGCCAA AAGGAGATGA AACTATTGCT GGATATGTAC CGTTCTGCCC CAAAGGAACA GAGAGACAAA GTTCAGCTGA TGGCAGCTGA GAAGAAGTCT AAGGCAGAGT TGGAAGATCT AAGGCAAAGA CTCAAGGATC TGGAAGATAA AGAGAAGAAA GAGAACAAGA AAATGGCTGA TGAGGATGCC TTGAGGAAGA TCCGGGCAGT GGAGGAGCAG ATAGAATACC TACAGAAGAA GCTAGCCATG GCCAAGCAGG AAGAAGAAGC ACTCCTCTCT GAAATGGATG TCACAGGCCA GGCCTTTGAA GACATGCAGG AGCAAAATAT CCGTTTGATG CAGCAATTGC GGGAGAAGGA TGATGCAAAT TTCAAGCTCA TGTCAGAGCG TATCAAGTCC AATCAGATCC ATAAGTTGCT TAAAGAAGAG AAGGAGGAGC TGGCAGACCA GGTGTTGACT CTGAAGACTC AGGTTGATGC CCAGCTACAG GTAGTAAGGA AACTGGAAGA GAAGGAGCAT CTGTTACAGA GCAACATTGG CACAGGGGAG AAAGAGCTGG GTCTTAGGAC CCAAGCCTTA GAGATGAATA AACGCAAGGC AATGGAGGCA GCCCAGCTTG CAGATGACCT CAAAGCACAA CTGGAGTTGG CTCAGAAGAA GCTACATGAT TTTCAGGATG AGATCGTGGA GAACAGTGTT ACCAAAGAAA AGGACATGTT CAATTTCAAA CGAGCCCAGG AGGACATCTC TAGACTTCGC AGGAAGCTGG AGACCACAAA GAAACCAGAC AATGTACCCA AGTGTGATGA GATTCTGATG GAAGAGATTA AGGATTACAA GGCACGCTTG ACCTGTCCGT GCTGTAACAT GCGTAAAAAG GATGCTGTTC TTACTAAGTG TTTTCATGTC TTCTGCTTTG AGTGTGTGAA GACACGCTAT GACACCCGCC AGCGCAAATG TCCCAAGTGT AATGCTGCTT TTGGTGCCAA TGATTTTCAT CGCATCTACA TTGGTTGA. It is sometimes possible for the material contained within the vial of "RNF20, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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