RBCK1 cdna clone
RBCK1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is similar to mouse UIP28/UbcM4 interacting protein. Alternative splicing has been observed at this locus, resulting in distinct isoforms. [provided by RefSeq, Jul 2008]
Uniprot Description
RBCK1: a E3 ubiquitin-protein ligase that contains a zf-RanBP (Zn-finger in Ran binding protein) and a zf-C3HC4 (RING finger) domain. Phosphorylation apparently reduces its E3 activity. Functions as a transcriptional activator. Its nuclear translocation is prevented by binding to a splice-variant of RBCK1 that lacks the RING finger domain. Interacts with PKCB1, PKCZ, and accepts ubiquitin from E2 ubiquitin-conjugating enzymes including UBE2L3. Interacts with PKCH. Interacts with the HBV pX/HBx protein, which is required to activate transcription of the viral genome. Three splice-variant isoforms of the human protein have been reported.
Protein type: Ligase; Ubiquitin ligase; EC 6.3.2.-; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 20p13
Cellular Component: cytosol
Molecular Function: protein binding; ubiquitin binding; ubiquitin-protein ligase activity
Biological Process: activation of NF-kappaB transcription factor; I-kappaB kinase/NF-kappaB cascade; inhibition of NF-kappaB transcription factor; positive regulation of I-kappaB kinase/NF-kappaB cascade; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; T cell receptor signaling pathway
Disease: Polyglucosan Body Myopathy, Early-onset, With Or Without Immunodeficiency
Research Articles on RBCK1
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Product Notes
The RBCK1 rbck1 (Catalog #AAA1273795) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggccctga gcctcacccg agcagtggcg ggcggggatg aacaggtggc aatgaagtgt gccatctggc tggcagagca acgggtgccc ctgagtgtgc aactgaagcc tgaggtctcc ccaacgcagg acatcaggct gtgggtgagc gtggaggatg ctcagatgca caccgtcacc atctggctca cagtgcgccc tgatatgaca gtggcgtctc tcaaggacat ggtttttctg gactatggct tcccaccagt cttgcagcag tgggtgattg ggcagcggct ggcacgagac caggagaccc tgcactccca tggggtgcgg cagaatgggg acagtgccta cctctatctg ctgtcagccc gcaacacctc cctcaaccct caggagctgc agcgggagcg gcagctgcgg atgctggaag atctgggctt caaggacctc acgctgcagc cgcggggccc tctggagcca ggccccccaa agcccggggt cccccaggaa cccggacggg ggcagccaga tgcagtgcct gagcccccac cggtgggctg gcagtgcccc gggtgcacct tcatcaacaa gcccacgcgg cctggctgtg agatgtgctg ccgggcgcgc cccgaggcct accaggtccc cgcctcatac cagcccgacg aggaggagcg agcgcgcctg gcgggcgagg aggaggcgct gcgtcagtac cagcagcgga agcagcagca gcaggagggg aactacctgc agcacgtcca gctggaccag aggagcctgg tgctgaacac ggagcccgcc gagtgccccg tgtgctactc ggtgctggcg cccggcgagg ccgtggtgct gcgtgagtgt ctgcacacct tctgcaggga gtgcctgcag ggcaccatcc gcaacagcca ggaggcggag gtctcctgcc ccttcattga caacacctac tcgtgctcgg gcaagctgct ggagagggag atcaaggcgc tcctgacccc tgaggattac cagcgatttc tagacctggg catctccatt gctgaaaacc gcagtgcctt cagctaccat tgcaagaccc cagattgcaa gggatggtgc ttctttgagg atgatgtcaa tgagttcacc tgccctgtgt gtttccacgt caactgcctg ctctgcaagg ccatccatga gcagatgaac tgcaaggagt atcaggagga cctggccctg cgggctcaga acgatgtggc tgcccggcag acgacagaga tgctgaaggt gatgctgcag cagggcgagg ccatgcgctg cccccagtgc cagatcgtgg tacagaagaa ggacggctgc gactggatcc gctgcaccgt ctgccacacc gagatctgct gggtcaccaa gggcccacgc tggggccctg ggggcccagg agacaccagc gggggctgcc gctgcagggt aaatgggatt ccttgccacc caagctgtca gaactgccac tga. It is sometimes possible for the material contained within the vial of "RBCK1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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