ARNTL2 cdna clone
ARNTL2 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Uniprot Description
ARNTL2: ARNTL2-CLOCK heterodimers activate E-box element (5'- CACGTG-5') transcription. Also, in umbilical vein endothelial cells, activates SERPINE1 through E-box sites. This transactivation is inhibited by PER2 and CRY1. 8 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 12p12.2-p11.2
Cellular Component: nucleolus; nucleus
Molecular Function: transcription factor activity
Biological Process: circadian rhythm; positive regulation of circadian rhythm; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter
Research Articles on ARNTL2
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Product Notes
The ARNTL2 arntl2 (Catalog #AAA1273556) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGCGGCGG AAGAGGAGGC TGCGGCGGGA GGTGAGGTTG CCGGTGGCGA GGCGACGGCC CCAGGTAAAG TGTTGAGAGA GGAGAACCAG TGCATTGCTC CTGTGGTTTC CAGCCGCGTG AGTCCAGGGA CAAGACCAAC AGCTATGGGG TCTTTCAGCT CACACATGAC AGAGTTTCCA CGAAAACGCA AAGGAAGTGA TTCAGACCCA TCCCAAGAAG CTCATAGCCA AACTGAAAAG CGGAGGAGAG ATAAAATGAA TAACCTGATT GAAGAACTGT CTGCAATGAT CCCTCAGTGC AACCCCATGG CGCGTAAACT GGACAAACTT ACAGTTTTAA GAATGGCTGT TCAACACTTG AGATCTTTAA AAGGCTTGAC AAATTCTTAT GTGGGAAGTA ATTATAGACC ATCATTTCTT CAGGATAATG AGCTCAGACA TTTAATCCTT AAGACTGCAG AAGGCTTCTT ATTTGTGGTT GGATGTGAAA GAGGAAAAAT TCTCTTCGTT TCTAAGTCAG TCTCCAAAAT ACTTAATTAT GATCAGGCTA GTTTGACTGG ACAAAGCTTA TTTGACTTCT TACATCCAAA AGATGTTGCC AAAGTAAAGG AACAACTTTC TTCTTTTGAT ATTTCACCAA GAGAAAAGCT AATAGATGCC AAAACTGGTT TGCAAGTTCA CAGTAATCTC CACGCTGGAA GGACACGTGT GTATTCTGGC TCAAGACGAT CTTTTTTCTG TCGGATAAAG AGTTGTAAAA TCTCTGTCAA AGAAGAGCAT GGATGCTTAC CCAACTCAAA GAAGAAAGAG CACAGAAAAT TCTATACTAT CCATTGCACT GGTTACTTGA GAAGCTGGCC TCCAAATATT GTTGGAATGG AAGAAGAAAG GAACAGTAAG AAAGACAACA GTAATTTTAC CTGCCTTGTG GCCATTGGAA GATTACAGCC ATATATTGTT CCACAGAACA GTGGAGAGAT TAATGTGAAA CCAACTGAAT TTATAACCCG GTTTGCAGTG AATGGAAAAT TTGTCTATGT AGATCAAAGG GCAACAGCGA TTTTAGGATA TCTGCCTCAG GAACTTTTGG GAACTTCTTG TTATGAATAT TTTCATCAAG ATGACCACAA TAATTTGACT GACAAGCACA AAGCAGTTCT ACAGAGTAAG GAGAAAATAC TTACAGATTC CTACAAATTC AGAGCAAAAG ATGGCTCTTT TGTAACTTTA AAAAGCCAAT GGTTTAGTTT CACAAATCCT TGGACAAAAG AACTGGAATA TATTGTATCT GTCAACACTT TAGTTTTGGG ACATAGTGAG CCTGGAGAAG CATCATTTTT ACCTTGTAGC TCTCAATCAT CAGAAGAATC CTCTAGACAG TCCTGTATGA GTGTACCTGG AATGTCTACT GGAACAGTAC TTGGTGCTGG TAGTATTGGA ACAGATATTG CAAATGAAAT TCTGGATTTA CAGAGGTTAC AGTCTTCTTC ATACCTTGAT GATTCGAGTC CAACAGGTTT AATGAAAGAT ACTCATACTG TAAACTGCAG GAGTATGTCA AATAAGGAGT TGTTTCCACC AAGTCCTTCT GAAATGGGGG AGCTAGAGGC TACCAGGCAA AACCAGAGTA CTGTTGCTGT CCACAGCCAT GAGCCACTCC TCAGTGATGG TGCACAGTTG GATTTCGATG CCCTATGTGA CAATGATGAC ACAGCCATGG CTGCATTTAT GAATTACTTA GAAGCAGAGG GGGGCCTGGG AGACCCTGGG GACTTCAGTG ACATCCAGTG GACCCTCTAG. It is sometimes possible for the material contained within the vial of "ARNTL2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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