TNFSF13B cdna clone
TNFSF13B cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
Uniprot Description
BAFF: Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis; Cell cycle regulation; Cytokine; Membrane protein, integral
Chromosomal Location of Human Ortholog: 13q32-q34
Cellular Component: cytoplasm; extracellular region; perinuclear region of cytoplasm
Molecular Function: protein binding; receptor binding
Biological Process: cell proliferation; positive regulation of B cell proliferation; positive regulation of cell proliferation; signal transduction; tumor necrosis factor-mediated signaling pathway
Research Articles on TNFSF13B
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Product Notes
The TNFSF13B tnfsf13b (Catalog #AAA1272359) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggatgact ccacagaaag ggagcagtca cgccttactt cttgccttaa gaaaagagaa gaaatgaaac tgaaggagtg tgtttccatc ctcccacgga aggaaagccc ctctgtccga tcctccaaag acggaaagct gctggctgca accttgctgc tggcactgct gtcttgctgc ctcacggtgg tgtctttcta ccaggtggcc gccctgcaag gggacctggc cagcctccgg gcagagctgc agggccacca cgcggagaag ctgccagcag gagcaggagc ccccaaggcc ggcctggagg aagctccagc tgtcaccgcg ggactgaaaa tctttgaacc accagctcca ggagaaggca actccagtca gaacagcaga aataagcgtg ccgttcaggg tccagaagaa acagtcactc aagactgctt gcaactgatt gcagacagtg aaacaccaac tatacaaaaa ggatcttaca catttgttcc atggcttctc agctttaaaa ggggaagtgc cctagaagaa aaagagaata aaatattggt caaagaaact ggttactttt ttatatatgg tcaggtttta tatactgata agacctacgc catgggacat ctaattcaga ggaagaaggt ccatgtcttt ggggatgaat tgagtctggt gactttgttt cgatgtattc aaaatatgcc tgaaacacta cccaataatt cctgctattc agctggcatt gcaaaactgg aagaaggaga tgaactccaa cttgcaatac caagagaaaa tgcacaaata tcactggatg gagatgtcac attttttggt gcattgaaac tgctgtga. It is sometimes possible for the material contained within the vial of "TNFSF13B, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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