HLA-DOB cdna clone
HLA-DOB cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
Uniprot Description
HLA-DOB: Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM. Belongs to the MHC class II family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: lysosomal membrane; lysosome; MHC class II protein complex
Molecular Function: MHC class II receptor activity
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; negative regulation of antigen processing and presentation of peptide antigen via MHC class II
Research Articles on HLA-DOB
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Product Notes
The HLA-DOB hla-dob (Catalog #AAA1270038) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgggttctg ggtgggtccc ctgggtggtg gctctgctag tgaatctgac ccgactggat tcctccatga ctcaaggcac agactctcca gaagattttg tgattcaggc aaaggctgac tgttacttca ccaacgggac agaaaaggtg cagtttgtgg tcagattcat ctttaacttg gaggagtatg tacgtttcga cagtgatgtg gggatgtttg tggcattgac caagctgggg cagccagatg ctgagcagtg gaacagccgg ctggatctct tggagaggag cagacaggcc gtggatgggg tctgtagaca caactacagg ctgggcgcac ccttcactgt ggggagaaaa gtgcaaccag aggtgacagt gtacccagag aggaccccac tcctgcacca gcataatctg ctgcactgct ctgtgacagg cttctatcca ggggatatca agatcaagtg gttcctgaat gggcaggagg agagagctgg ggtcatgtcc actggcccta tcaggaatgg agactggacc tttcagactg tggtgatgct agaaatgact cctgaacttg gacatgtcta cacctgcctt gtcgatcact ccagcctgct gagccctgtt tctgtggagt ggagagctca gtctgaatat tcttggagaa agatgctgag tggcattgca gccttcctac ttgggctaat cttccttctg gtgggaatcg tcatccagct aagggctcag aaaggatatg tgaggacgca gatgtctggt aatgaggtct caagagctgt tctgctccct cagtcatgct aa. It is sometimes possible for the material contained within the vial of "HLA-DOB, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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