MAOA cdna clone
MAOA cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]
Uniprot Description
MAOA: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine. Defects in MAOA are the cause of Brunner syndrome (BRUNS). Brunner syndrome is a form of X-linked non- dysmorphic mild mental retardation. Male patients are affected by a syndrome of borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior. Belongs to the flavin monoamine oxidase family.
Protein type: EC 1.4.3.4; Amino Acid Metabolism - histidine; Membrane protein, integral; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - glycine, serine and threonine; Amino Acid Metabolism - phenylalanine; Oxidoreductase; Amino Acid Metabolism - tryptophan
Chromosomal Location of Human Ortholog: Xp11.3
Cellular Component: mitochondrial outer membrane; mitochondrion
Molecular Function: amine oxidase activity
Biological Process: biogenic amine metabolic process; dopamine catabolic process; neurotransmitter metabolic process
Disease: Brunner Syndrome
Research Articles on MAOA
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Product Notes
The MAOA maoa (Catalog #AAA1269315) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggagaatc aagagaaggc gagtatcgcg ggccacatgt tcgacgtagt cgtgatcgga ggtggcattt caggactatc tgctgccaaa ctcttgactg aatatggcgt tagtgttttg gttttagaag ctcgggacag ggttggagga agaacatata ctataaggaa tgagcatgtt gattacgtag atgttggtgg agcttatgtg ggaccaaccc aaaacagaat cttacgcttg tctaaggagc tgggcataga gacttacaaa gtgaatgtca gtgagcgtct cgttcaatat gtcaagggga aaacatatcc atttcggggc gcctttccac cagtatggaa tcccattgca tatttggatt acaataatct gtggaggaca atagataaca tggggaagga gattccaact gatgcaccct gggaggctca acatgctgac aaatgggaca aaatgaccat gaaagagctc attgacaaaa tctgctggac aaagactgct aggcggtttg cttatctttt tgtgaatatc aatgtgacct ctgagcctca cgaagtgtct gccctgtggt tcttgtggta tgtgaagcag tgcgggggca ccactcggat attctctgtc accaatggtg gccaggaacg gaagtttgta ggtggatctg gtcaagtgag cgaacggata atggacctcc tcggagacca agtgaagctg aaccatcctg tcactcacgt tgaccagtca agtgacaaca tcatcataga gacgctgaac catgaacatt atgagtgcaa atacgtaatt aatgcgatcc ctccgacctt gactgccaag attcacttca gaccagagct tccagcagag agaaaccagt taattcagcg gcttccaatg ggagctgtca ttaagtgcat gatgtattac aaggaggcct tctggaagaa gaaggattac tgtggctgca tgatcattga agatgaagat gctccaattt caataacctt ggatgacacc aagccagatg ggtcactgcc tgccatcatg ggcttcattc ttgcccggaa agctgatcga cttgctaagc tacataagga aataaggaag aagaaaatct gtgagctcta tgccaaagtg ctgggatccc aagaagcttt acatccagtg cattatgaag agaagaactg gtgtgaggag cagtactctg ggggctgcta cacggcctac ttccctcctg ggatcatgac tcaatatgga agggtgattc gtcaacccgt gggcaggatt ttctttgcgg gcacagagac tgccacaaag tggagcggct acatggaagg ggcagttgag gctggagaac gagcagctag ggaggtctta aatggtctcg ggaaggtgac cgagaaagat atctgggtac aagaacctga atcaaaggac gttccagcgg tagaaatcac ccacaccttc tgggaaagga acctgccctc tgtttctggc ctgctgaaga tcattggatt ttccacatca gtaactgccc tggggtttgt gctgtacaaa tacaagctcc tgccacggtc ttga. It is sometimes possible for the material contained within the vial of "MAOA, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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