Rabbit TBX2 Polyclonal Antibody | anti-TBX2 antibody

TBX2 Rabbit Polyclonal

Cat. Num. AAA7604769

• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: TBX2; Polyclonal Antibody; TBX2 Rabbit Polyclonal; anti-TBX2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 712

• Applicable Applications for anti-TBX2 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: T-box 2
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human kidney using MBS7604769 (TBX2 antibody) at dilution of 1:100)

Western Blot (WB)

(mouse lung tissue were subjected to SDS PAGE followed by western blot with MBS7604769 (TBX2 Antibody) at dilution of 1:300)

NCBI and Uniprot Product Information

• NCBI GI #: 197333868
• NCBI GeneID: 6909
• NCBI Accession #: NP_005985.3
• NCBI GenBank Nucleotide #: NM_005994.3
• Molecular Weight: 75,066 Da
• NCBI Official Full Name: T-box transcription factor TBX2
• NCBI Official Synonym Full Names: T-box 2
• NCBI Official Symbol: TBX2
• NCBI Protein Information: T-box transcription factor TBX2
• UniProt Protein Name: T-box transcription factor TBX2
• Protein Family: T-box transcription factor
• UniProt Gene Name: TBX2
• UniProt Synonym Gene Names: T-box protein 2
• UniProt Entry Name: TBX2_HUMAN

NCBI Description

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

TBX2: Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Expressed primarily in adult in kidney, lung, and placenta. Weak expression in heart and ovary.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 17q23.2

Cellular Component: nucleus; transcription factor complex

Molecular Function: DNA binding; protein binding; sequence-specific DNA binding

Biological Process: cardiac muscle development; cell aging; embryonic camera-type eye morphogenesis; embryonic digit morphogenesis; embryonic heart tube development; heart looping; muscle cell fate determination; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; Notch signaling pathway; palate development; positive regulation of cardiac muscle cell proliferation; positive regulation of cell proliferation; regulation of heart contraction; transcription, DNA-dependent