FIP1L1 cdna clone
FIP1L1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Uniprot Description
FIP1L1: a component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre- mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. A fusion of FIP1L1 and PDGFRA (FIP1L1-PDGFRA) is the cause of some cases of hypereosinophilic syndrome (HES), a disorder characterized by overproduction of eosinophils in the bone marrow, eosinophilia, tissue infiltration and organ damage. Four alternatively spliced isoforms have been described.
Protein type: RNA-binding; RNA processing
Chromosomal Location of Human Ortholog: 4q12
Cellular Component: nucleoplasm
Molecular Function: protein binding
Biological Process: mRNA 3'-end processing; mRNA export from nucleus; nuclear mRNA splicing, via spliceosome; termination of RNA polymerase II transcription
Disease: Hypereosinophilic Syndrome, Idiopathic
Research Articles on FIP1L1
Similar Products
Product Notes
The FIP1L1 fip1l1 (Catalog #AAA1266519) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGTCGGCCG GCGAGGTCGA GCGCCTAGTG TCGGAGCTGA GCGGCGGGAC CGGAGGGGAT GAGGAGGAAG AGTGGCTCTA TGGCGGCCCA TGGGACGTGC ATGTGCACAG TGATTTGGCA AAGGACCTAG ATGAAAATGA AGTTGAAAGG CCAGAAGAAG AAAATGCCAG TGCTAATCCT CCATCTGGAA TTGAAGATGA AACTGCTGAA AATGGTGTAC CAAAACCGAA AGTGACTGAG ACCGAAGATG ATAGTGATAG TGACAGCGAT GATGATGAAG ATGATGTTCA TGTCACTATA GGAGACATTA AAACGGGAGC ACCACAGTAT GGGAGTTATG GTACAGCACC TGTAAATCTT AACATCAAGA CAGGGGGAAG AGTTTATGGA ACTACAGGGA CAAAAGTCAA AGGAGTAGAC CTTGATGCAC CTGGAAGCAT TAATGGAGTT CCACTCTTAG AGGTAGATTT GGATTCTTTT GAAGATAAAC CATGGCGTAA ACCTGGTGCT GATCTTTCTG ATTATTTTAA TTATGGGTTT AATGAAGATA CCTGGAAAGC TTACTGTGAA AAACAAAAGA GGATACGAAT GGGACTTGAA GTTATACCAG TAACCTCTAC TACAAATAAA ATTACGGCCG AAGACTGTAC TATGGAAGTT ACACCAGGTG CAGAGATCCA AGATGGCAGA TTCAATCTTT TTAAGGTACA GCAGGGAAGA ACTGGAAACT CAGAGAAAGA AACTGCCCTT CCATCTACAA AAGCTGAGTT TACTTCTCCT CCTTCTTTGT TCAAGACTGG GCTTCCACCG AGCAGAAACA GCACTTCTTC TCAGTCTCAG ACAAGTACTG CCTCCAGAAA AGCCAATTCA AGCGTTGGGA AGTGGCAGGA TCGATATGGG AGGGCCGAAT CACCTGATCT AAGGAGATTA CCTGGGGCAA TTGATGTTAT CGGTCAGACT ATAACTATCA GCCGAGTAGA AGGCAGGCGA CGGGCAAATG AGAACAGCAA CATACAGGTC CTTTCTGAAA GATCTGCTAC TGAAGTAGAC AACAATTTTA GCAAACCACC TCCGTTTTTC CCTCCAGGAG CTCCTCCCAC TCACCTTCCA CCTCCTCCAT TTCTTCCACC TCCTCCGACT GTCAGCACTG CTCCACCTCT GATTCCACCA CCGGGTTTTC CTCCTCCACC AGGCGCTCCA CCTCCATCTC TTATACCAAC AATAGAAAGT GGACATTCCT CTGGTTATGA TAGTCGTTCT GCACGTGCAT TTCCATATGG CAATGTTGCC TTTCCCCATC TTCCTGGTTC TGCTCCTTCG TGGCCTAGTC TTGTGGACAC CAGCAAGCAG TGGGACTATT ATGCCAGAAG AGAGAAAGAC CGAGATAGAG AGAGAGACAG AGACAGAGAG CGAGACCGTG ATCGGGACAG AGAAAGAGAA CGCACCAGAG AGAGAGAGAG GGAGCGTGAT CACAGTCCTA CACCAAGTGT TTTCAACAGC GATGAAGAAC GATACAGATA CAGGGAATAT GCAGAAAGAG GTTATGAGCG TCACAGAGCA AGTCGAGAAA AAGAAGAACG ACATAGAGAA AGACGACACA GGGAGAAAGA GGAAACCAGA CATAAGTCTT CTCGAAGTAA TAGTAGACGT CGCCATGAAA GTGAAGAAGG AGATAGTCAC AGGAGACACA AACACAAAAA ATCTAAAAGA AGCAAAGAAG GAAAAGAAGC GGGCAGTGAG CCTGCCCCTG AACAGGAGAG CACCGAAGCT ACACCTGCAG AATAG. It is sometimes possible for the material contained within the vial of "FIP1L1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
