CLNS1A cdna clone
CLNS1A cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]
Uniprot Description
ICLN: The interaction with Sm proteins inhibits their assembly on U RNA and interferes with snRNP biogenesis. Inhibits the binding of survival motor neuron protein (SMN) to Sm proteins. May participate in cellular volume control by activation of a swelling-induced chloride conductance pathway. Belongs to the pICln (TC 1.A.47) family.
Protein type: Channel, chloride
Chromosomal Location of Human Ortholog: 11q13.5-q14
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: protein binding; protein heterodimerization activity
Biological Process: spliceosomal snRNP biogenesis
Research Articles on CLNS1A
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Product Notes
The CLNS1A clns1a (Catalog #AAA1266133) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGAGCTTCC TCAAAAGTTT CCCGCCGCCT GGGCCAGCGG AGGGGCTCCT GCGGCAGCAG CCAGACACTG AGGCTGTGCT GAACGGGAAG GGCCTCGGCA CTGGTACCCT TTACATCGCT GAGAGCCGCC TGTCTTGGTT AGATGGCTCT GGATTAGGAT TCTCACTGGA ATACCCCACC ATTAGTTTAC ATGCATTATC CAGGGACCGA AGTGACTGTC TAGGAGAGCA TTTGTATGTT ATGGTGAATG CCAAATTTGA AGAAGAATCA AAAGAACCTG TTGCTGATGA AGAAGAGGAA GACAGTGATG ATGATGTTGA ACCTATTACT GAATTTAGAT TTGTGCCTAG TGATAAATCA GCGTTGGAGG CAATGTTCAC TGCAATGTGC GAATGCCAGG CCTTGCATCC AGATCCTGAG GATGAGGATT CAGATGACTA CGATGGAGAA GAATATGATG TGGAAGCACA TGAACAAGGA CAGGGGGACA TCCCTACATT TTACACCTAT GAAGAAGGAT TATCCCATCT AACAGCAGAA GGCCAAGCCA CACTGGAGAG ATTAGAAGGA ATGCTTTCTC AGTCTGTGAG CAGCCAGTAT AATATGGCTG GGGTCAGGAC AGAAGATTCA ATAAGAGATT ATGAAGATGG GATGGAGGTG GATACCACAC CAACAGTTGC TGGACAGTTT GAGGATGCAG ATGTTGATCA CTGA. It is sometimes possible for the material contained within the vial of "CLNS1A, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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