Western Blot (WB)
(HEK-293 cells were subjected to SDS PAGE followed by western blot with MBS7600342 (Icln antibody) at dilution of 1:1000)
Rabbit anti-Human, Dog Icln Polyclonal Antibody | anti-Icln antibody
Icln Rabbit Polyclonal
Immunogen Affinity Purified
Immunogen Affinity Purified
Western Blot (WB)
(HEK-293 cells were subjected to SDS PAGE followed by western blot with MBS7600342 (Icln antibody) at dilution of 1:1000)
Western Blot (WB)
(HEK-293 cells were subjected to SDS PAGE followed by western blot with MBS7600342 (Icln antibody) at dilution of 1:1000)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]
Uniprot Description
ICLN: The interaction with Sm proteins inhibits their assembly on U RNA and interferes with snRNP biogenesis. Inhibits the binding of survival motor neuron protein (SMN) to Sm proteins. May participate in cellular volume control by activation of a swelling-induced chloride conductance pathway. Belongs to the pICln (TC 1.A.47) family.
Protein type: Channel, chloride
Chromosomal Location of Human Ortholog: 11q13.5-q14
Cellular Component: cytoplasm; cytoskeleton; cytosol; nucleoplasm; nucleus; plasma membrane
Molecular Function: protein binding; protein heterodimerization activity
Biological Process: cell volume homeostasis; chloride transport; spliceosomal snRNP biogenesis
Research Articles on Icln
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Product Notes
The Icln clns1a (Catalog #AAA7600342) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Icln Rabbit Polyclonal reacts with Human, Dog and may cross-react with other species as described in the data sheet. AAA Biotech's Icln can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Researchers should empirically determine the suitability of the Icln clns1a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Icln, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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