U5 small nuclear ribonucleoprotein 200 kDa helicase (SNRNP200) Recombinant Protein | SNRNP200 recombinant protein
Recombinant Human U5 small nuclear ribonucleoprotein 200 kDa helicase (SNRNP200) , partial
NCBI and Uniprot Product Information
NCBI Description
Pre-mRNA splicing is catalyzed by the spliceosome, a complex of specialized RNA and protein subunits that removes introns from a transcribed pre-mRNA segment. The spliceosome consists of small nuclear RNA proteins (snRNPs) U1, U2, U4, U5 and U6, together with approximately 80 conserved proteins. U5 snRNP contains nine specific proteins. This gene encodes one of the U5 snRNP-specific proteins. This protein belongs to the DEXH-box family of putative RNA helicases. It is a core component of U4/U6-U5 snRNPs and appears to catalyze an ATP-dependent unwinding of U4/U6 RNA duplices. Mutations in this gene cause autosomal-dominant retinitis pigmentosa. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined. [provided by RefSeq, Mar 2010]
Uniprot Description
RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome.
Research Articles on SNRNP200
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Product Notes
The SNRNP200 snrnp200 (Catalog #AAA1154258) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1808-2136aa; Partial. The amino acid sequence is listed below: MDVAPLNLGM IAAYYYINYT TIELFSMSLN AKTKVRGLIE IISNAAEYEN IPIRHHEDNL LRQLAQKVPH KLNNPKFNDP HVKTNLLLQA HLSRMQLSAE LQSDTEEILS KAIRLIQACV DVLSSNGWLS PALAAMELAQ MVTQAMWSKD SYLKQLPHFT SEHIKRCTDK GVESVFDIME MEDEERNALL QLTDSQIADV ARFCNRYPNI ELSYEVVDKD SIRSGGPVVV LVQLEREEEV TGPVIAPLFP QKREEGWWVV IGDAKSNSLI SIKRLTLQQK AKVKLDFVAP ATGAHNYTLY FMSDAYMGCD QEYKFSVDVK EAETDSDSD . It is sometimes possible for the material contained within the vial of "U5 small nuclear ribonucleoprotein 200 kDa helicase (SNRNP200), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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