Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using SNRNP200 antibody.)
Rabbit anti-Human, Mouse SNRNP200 Polyclonal Antibody | anti-SNRNP200 antibody
SNRNP200 (Small Nuclear Ribonucleoprotein 200kD, BRR2, RP33, HELIC2, ASCC3L1, U5-200KD) (PE)
WB: 1:500-1:1000
Applications are based on unconjugated antibody.
Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using SNRNP200 antibody.)
Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using SNRNP200 antibody.)
NCBI and Uniprot Product Information
NCBI Description
Pre-mRNA splicing is catalyzed by the spliceosome, a complex of specialized RNA and protein subunits that removes introns from a transcribed pre-mRNA segment. The spliceosome consists of small nuclear RNA proteins (snRNPs) U1, U2, U4, U5 and U6, together with approximately 80 conserved proteins. U5 snRNP contains nine specific proteins. This gene encodes one of the U5 snRNP-specific proteins. This protein belongs to the DEXH-box family of putative RNA helicases. It is a core component of U4/U6-U5 snRNPs and appears to catalyze an ATP-dependent unwinding of U4/U6 RNA duplices. Mutations in this gene cause autosomal-dominant retinitis pigmentosa. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined. [provided by RefSeq, Mar 2010]
Uniprot Description
U5-200kD: Putative RNA helicase involved in the second step of RNA splicing. May promote one or more conformational changes in the dynamic network of RNA-RNA interactions in the spliceosome. Appears to catalyze an ATP-dependent unwinding of U4/U6 RNA duplices. Defects in SNRNP200 are the cause of retinitis pigmentosa type 33 (RP33). It is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Belongs to the helicase family. SKI2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: RNA splicing; Spliceosome; RNA-binding; Helicase; EC 3.6.4.13; RNA processing
Chromosomal Location of Human Ortholog: 2q11.2
Cellular Component: nucleoplasm; spliceosome; membrane; snRNP U5; nucleus
Molecular Function: identical protein binding; protein binding; ATP-dependent helicase activity; ATP-dependent RNA helicase activity; ATP binding
Biological Process: osteoblast differentiation; nuclear mRNA splicing, via spliceosome; cis assembly of pre-catalytic spliceosome; RNA splicing; gene expression
Disease: Retinitis Pigmentosa 33
Research Articles on SNRNP200
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Product Notes
The SNRNP200 snrnp200 (Catalog #AAA6438452) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SNRNP200 (Small Nuclear Ribonucleoprotein 200kD, BRR2, RP33, HELIC2, ASCC3L1, U5-200KD) (PE) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's SNRNP200 can be used in a range of immunoassay formats including, but not limited to, Immunoprecipitation (IP), Western Blot (WB). IP: 1:20-1:50 WB: 1:500-1:1000 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the SNRNP200 snrnp200 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SNRNP200, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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