3-hydroxyacyl-CoA dehydratase 1 (PTPLA) Recombinant Protein | PTPLA recombinant protein

Recombinant Human 3-hydroxyacyl-CoA dehydratase 1 (PTPLA)

• Gene Names: PTPLA; CAP; HACD1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: 3-hydroxyacyl-CoA dehydratase 1 (PTPLA); Recombinant Human 3-hydroxyacyl-CoA dehydratase 1 (PTPLA); Recombinant 3-hydroxyacyl-CoA dehydratase 1 (PTPLA); 3-hydroxyacyl-CoA dehydratase 1; HACD1 EC= 4.2.1.-; Cementum attachment protein Protein-tyrosine phosphatase-like member A; PTPLA recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-288
• Sequence: MGRLTEAAAAGSGSRAAGWAGSPPTLLPLSPTSPRCAATMASSDEDGTNGGASEAGEDREAPGERRRLGVLATAWLTFYDIAMTAGWLVLAIAMVRFYMEKGTHRGLYKSIQKTLKFFQTFALLEIVHCLIGIVPTSVIVTGVQVSSRIFMVWLITHSIKPIQNEESVVLFLVAWTVTEITRYSFYTFSLLDHLPYFIKWARYNFFIILYPVGVAGELLTIYAALPHVKKTGMFSIRLPNKYNVSFDYYYFLLITMASYIPLFPQLYFHMLRQRRKVLHGEVIVEKDD
• Sequence Length: 288

• Species: Homo sapiens (Human)
• Preparation and Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 82659105
• NCBI GeneID: 9200
• NCBI Accession #: NP_055056.3
• NCBI GenBank Nucleotide #: NM_014241.3
• UniProt Accession #: B0YJ81; Q6JIC5; Q96FW7; Q9HB93; Q9UHX2; B0YJ80
• Molecular Weight: 32,388 Da
• NCBI Official Full Name: very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 1
• NCBI Official Synonym Full Names: protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
• NCBI Official Symbol: PTPLA
• NCBI Official Synonym Symbols: CAP; HACD1
• NCBI Protein Information: very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 1; very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 1; cementum attachment protein; 3-hydroxyacyl-CoA dehydratase 1; protein-tyrosine phosphatase-like member A
• UniProt Protein Name: Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 1
• UniProt Gene Name: PTPLA
• UniProt Synonym Gene Names: HACD1; HACD1
• UniProt Entry Name: HACD1_HUMAN

NCBI Description

The protein encoded by this gene contains a characteristic catalytic motif of the protein tyrosine phosphatases (PTPs) family. The PTP motif of this protein has the highly conserved arginine residue replaced by a proline residue; thus it may represent a distinct class of PTPs. Members of the PTP family are known to be signaling molecules that regulate a variety of cellular processes. This gene was preferentially expressed in both adult and fetal heart. A much lower expression level was detected in skeletal and smooth muscle tissues, and no expression was observed in other tissues. The tissue specific expression in the developing and adult heart suggests a role in regulating cardiac development and differentiation. [provided by RefSeq, Jul 2008]

Uniprot Description

PTPLA: Responsible for the dehydration step in very long-chain fatty acids (VLCFAs) synthesis. Belongs to the very long-chain fatty acids dehydratase HACD family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; EC 4.2.1.134; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 10p12.33

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane

Molecular Function: enzyme binding; hydroxyapatite binding; lyase activity; 3-hydroxyacyl-CoA dehydratase activity

Biological Process: sphingolipid biosynthetic process; multicellular organismal development; very-long-chain fatty acid biosynthetic process; regulation of G2/M transition of mitotic cell cycle; myotube differentiation; fatty acid elongation; fatty acid biosynthetic process