Rabbit anti-Human CHAT Polyclonal Antibody | anti-CHAT antibody

CHAT Polyclonal Antibody

Cat. Num. AAA9132313

• Gene Names: CHAT; CMS6; CMS1A; CMS1A2; CHOACTASE
• Reactivity: Human
• Applications: Immunofluorescence
• Purity: Affinity Purification
• Synonyms: CHAT; Polyclonal Antibody; CHAT Polyclonal Antibody; CHOACTASE; CMS1A; CMS1A2; CMS6; anti-CHAT antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Sequence Length: 748

• Applicable Applications for anti-CHAT antibody: Immunofluorescence (IF)
• Application Notes: IF: 1:50 - 1:100
• Immunogen: Recombinant protein of human CHAT
• Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunofluorescence (IF)

(Immunofluorescence analysis of MCF-7 cells using CHAT antibody.)

Related Product Information for anti-CHAT antibody

This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform.

Product Categories/Family for anti-CHAT antibody

Primary antibody

NCBI and Uniprot Product Information

• NCBI GI #: 281185509
• NCBI GeneID: 1103
• UniProt Accession #: P28329; Q16488; Q9BQ23; Q9BQ35; Q9BQE1; A2BDF4; A2BDF5
• Molecular Weight: 83kDa
• NCBI Official Full Name: Choline O-acetyltransferase
• NCBI Official Synonym Full Names: choline O-acetyltransferase
• NCBI Official Symbol: CHAT
• NCBI Official Synonym Symbols: CMS6; CMS1A; CMS1A2; CHOACTASE
• NCBI Protein Information: choline O-acetyltransferase
• UniProt Protein Name: Choline O-acetyltransferase
• Protein Family: (Z)-3-hexen-1-ol acetyltransferase
• UniProt Gene Name: CHAT
• UniProt Synonym Gene Names: CHOACTase; ChAT; Choline acetylase

NCBI Description

This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq, May 2010]

Uniprot Description

CHAT: an enzyme that catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. Four alternative splice variants have been described.

Protein type: Acetyltransferase; EC 2.3.1.6; Lipid Metabolism - glycerophospholipid

Chromosomal Location of Human Ortholog: 10q11.23

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: choline O-acetyltransferase activity

Biological Process: neurotransmitter secretion; phosphatidylcholine biosynthetic process

Disease: Myasthenic Syndrome, Congenital, Associated With Episodic Apnea