Transcription factor E2F6 (E2F6) Recombinant Protein | E2F6 recombinant protein

Recombinant Human Transcription factor E2F6 (E2F6)

Cat. Num. AAA1034351

• Gene Names: E2F6; E2F-6
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Transcription factor E2F6 (E2F6); Recombinant Human Transcription factor E2F6 (E2F6); Transcription factor E2F6; E2F-6; E2F6 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-281aa; Full Length
• Sequence: MSQQRPARKLPSLLLDPTEETVRRRCRDPINVEGLLPSKIRINLEDNVQYVSMRKALKVKRPRFDVSLVYLTRKFMDLVRSAPGGILDLNKVATKLGVRKRRVYDITNVLDGIDLVEKKSKNHIRWIGSDLSNFGAVPQQKKLQEELSDLSAMEDALDELIKDCAQQLFELTDDKENERLAYVTYQDIHSIQAFHEQIVIAVKAPAETRLDVPAPREDSITVHIRSTNGPIDVYLCEVEQGQTSNKRSEGVGTSSSESTHPEGPEEEENPQQSEELLEVSN
• Sequence Length: 281

• Species: Homo sapiens (Human)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

SDS-PAGE

Related Product Information for E2F6 recombinant protein

Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase.

Product Categories/Family for E2F6 recombinant protein

Epigenetics and Nuclear Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 506949344
• NCBI GeneID: 1876
• NCBI Accession #: NP_001265204.1
• NCBI GenBank Nucleotide #: NM_001278275.1
• UniProt Accession #: O75461; O60544; Q53QY9; Q6Q9Z6; Q7Z2H6; A8K2Z8; G5E936
• Molecular Weight: 58.8 kDa
• NCBI Official Full Name: transcription factor E2F6 isoform 2
• NCBI Official Synonym Full Names: E2F transcription factor 6
• NCBI Official Symbol: E2F6
• NCBI Official Synonym Symbols: E2F-6
• NCBI Protein Information: transcription factor E2F6
• UniProt Protein Name: Transcription factor E2F6
• Protein Family: Transcription factor
• UniProt Gene Name: E2F6
• UniProt Synonym Gene Names: E2F-6
• UniProt Entry Name: E2F6_HUMAN

NCBI Description

This gene encodes a member of a family of transcription factors that play a crucial role in the control of the cell cycle. The protein encoded by this gene lacks the transactivation and tumor suppressor protein association domains found in other family members, and contains a modular suppression domain that functions in the inhibition of transcription. It interacts in a complex with chromatin modifying factors. There are pseudogenes for this gene on chromosomes 22 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Uniprot Description

E2F6: Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase. Belongs to the E2F/DP family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 2p25.1

Cellular Component: transcription factor complex; nucleus

Molecular Function: DNA binding; transcription factor activity; transcription corepressor activity

Biological Process: G1/S-specific transcription in mitotic cell cycle; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter