DNA protection during starvation protein (dps) Recombinant Protein | dps recombinant protein

Recombinant Escherichia coli DNA protection during starvation protein (dps)

Cat. Num. AAA1007954

• Gene Names: dps; ECK0801; JW0797; pexB; vtm
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: DNA protection during starvation protein (dps); Recombinant Escherichia coli DNA protection during starvation protein (dps); dps recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 2-167, full length protein
• Sequence: STAKLVKSKATNLLYTRNDVSDSEKKATVELLNRQVIQFIDLSLITKQAHWNMRGANFIAVHEMLDGFRTALIDHLDTMAERAVQLGGVALGTTQVINSKTPLKSYPLDIHNVQDHLKELADRYAIVANDVRKAIGEAKDDDTADILTAASRDLDKFLWFIESNIE
• Sequence Length: 166

• Species: Escherichia coli (strain K12)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 16128780
• NCBI GeneID: 945101
• NCBI Accession #: NP_415333.1
• NCBI GenBank Nucleotide #: NC_000913.3
• UniProt Accession #: P0ABT2; P27430
• Molecular Weight: 18,695 Da
• NCBI Official Full Name: Fe-binding and storage protein; stress-inducible DNA-binding protein
• NCBI Official Symbol: dps
• NCBI Official Synonym Symbols: ECK0801; JW0797; pexB; vtm
• NCBI Protein Information: Fe-binding and storage protein; stress-inducible DNA-binding protein
• UniProt Protein Name: DNA protection during starvation protein
• Protein Family: Dehydrodolichyl diphosphate synthase
• UniProt Gene Name: dps
• UniProt Synonym Gene Names: pexB; vtm

NCBI Description

dps is required for growth below 8C, which is enabled by transgenic Oleispira antarctica Cpn10/60. [More information is available at EcoGene: EG11415]. Dps is a highly abundant protein in stationary-phase Escherichia coli and is required for the normal starvation response and long-term stationary phase viability . [More information is available at EcoCyc: EG11415].

Uniprot Description

During stationary phase, binds the chromosome non-specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction. Dps also protects the cell from UV and gamma irradiation, iron and copper toxicity, thermal stress and acid and base shocks. Also shows a weak catalase activity.