Sortilin 1 (SORT1) Protein | SORT1 protein

Eukaryotic Sortilin 1 (SORT1)

Cat. Num. AAA2086756

• Gene Names: SORT1; NT3; Gp95; NTR3; LDLCQ6
• Applications: SDS-Page, Western Blot
• Purity: > 90%
• Synonyms: Sortilin 1 (SORT1); Eukaryotic Sortilin 1 (SORT1); NT3; Gp95; NTR3; 100 kDa NT receptor; Glycoprotein 95; Neurotensin receptor 3; SORT1 protein

• Host: 293F cell
• Purity/Purification: > 90%
• Form/Format: Freeze-dried powder
• Sequence Length: 694

• Applicable Applications for SORT1 protein: Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)
• Tag: N-terminal His Tag
• Buffer Formulation: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Source Note: Eukaryotic expression
• Organism Species: Mouse
• Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
• Usage: Reconstitute in PBS or others.
• Preparation and Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

SDS-Page

Product Categories/Family for SORT1 protein

Eukaryotic proteins

NCBI and Uniprot Product Information

• NCBI GI #: 327315343
• NCBI GeneID: 6272
• NCBI Accession #: NP_001192157.1
• NCBI GenBank Nucleotide #: NM_001205228.1
• UniProt Accession #: Q99523; Q8IZ49; B4DWI3; C0JYZ0
• Molecular Weight: 77,375 Da
• NCBI Official Full Name: sortilin isoform 2
• NCBI Official Synonym Full Names: sortilin 1
• NCBI Official Symbol: SORT1
• NCBI Official Synonym Symbols: NT3; Gp95; NTR3; LDLCQ6
• NCBI Protein Information: sortilin
• UniProt Protein Name: Sortilin
• Protein Family: Sortilin
• UniProt Gene Name: SORT1
• UniProt Synonym Gene Names: Gp95; NT3; NTR3

NCBI Description

This gene encodes a member of the VPS10-related sortilin family of proteins. The encoded preproprotein is proteolytically processed by furin to generate the mature receptor. This receptor plays a role in the trafficking of different proteins to either the cell surface, or subcellular compartments such as lysosomes and endosomes. Expression levels of this gene may influence the risk of myocardial infarction in human patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

Uniprot Description

SORT1: Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. A common polymorphism located in a non-coding region between CELSR2 and PSRC1 alters a CEBP transcription factor binding site and is responsible for changes in hepatic expression of SORT1. Altered SORT1 expression in liver affects low density lipoprotein cholesterol levels in plasma and is associated with susceptibility to myocardial infarction. Belongs to the VPS10-related sortilin family. SORT1 subfamily.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1p13.3|1p21.3-p13.1

Cellular Component: cell surface; clathrin-coated vesicle; coated pit; cytoplasmic vesicle; early endosome; Golgi apparatus; integral to membrane; perinuclear region of cytoplasm; plasma membrane

Molecular Function: enzyme binding; nerve growth factor binding; nerve growth factor receptor activity; neurotensin receptor activity, non-G-protein coupled; protein binding

Biological Process: endocytosis; endosome to lysosome transport; endosome transport via multivesicular body sorting pathway; G-protein coupled receptor protein signaling pathway; glucose import; Golgi to endosome transport; induction of apoptosis via death domain receptors; myotube differentiation; negative regulation of lipoprotein lipase activity; nerve growth factor receptor signaling pathway; neuropeptide signaling pathway; plasma membrane to endosome transport; regulation of gene expression; response to insulin stimulus; vesicle organization and biogenesis

Disease: Low Density Lipoprotein Cholesterol Level Quantitative Trait Locus 6