Mouse zinc finger, RAN-binding domain containing 3 ELISA Kit | ZRANB3 elisa kit
Mouse Zinc finger Ran-binding domain-containing protein 3, ZRANB3 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
ZRANB3: DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks. Belongs to the SNF2/RAD54 helicase family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.6.1.-; Helicase; EC 3.6.4.-
Cellular Component: nuclear replication fork; chromosome; nucleus
Molecular Function: nuclease activity; zinc ion binding; hydrolase activity; metal ion binding; nucleotide binding; helicase activity; T/G mismatch-specific endonuclease activity; phosphoric ester hydrolase activity; endodeoxyribonuclease activity; DNA binding; nucleic acid binding; endonuclease activity; catalytic activity; ATP binding
Biological Process: negative regulation of DNA recombination; metabolic process; DNA strand renaturation; replication fork protection; DNA repair; response to DNA damage stimulus; DNA catabolic process, endonucleolytic; response to UV; replication fork processing
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Product Notes
The Mouse ZRANB3 zranb3 (Catalog #AAA9321652) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9321652 ELISA Kit recognizes Mouse ZRANB3. It is sometimes possible for the material contained within the vial of "zinc finger, RAN-binding domain containing 3, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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