Human zinc finger, FYVE domain containing 9 ELISA Kit | ZFYVE9 elisa kit
Human Zinc finger FYVE domain-containing protein 9, ZFYVE9 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a double zinc finger motif-containing protein that participates in the transforming growth factor-beta (TGFB) signalling pathway. The encoded protein interacts directly with SMAD2 and SMAD3, and recruits SMAD2 to the TGFB receptor. There are multiple pseudogenes for this gene on chromosomes 2, 15, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Uniprot Description
SARA: Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 1p32.3
Cellular Component: early endosome membrane; early endosome
Molecular Function: protein binding; serine-type peptidase activity; metal ion binding; phosphatidylinositol binding
Biological Process: transforming growth factor beta receptor signaling pathway; endocytosis; SMAD protein nuclear translocation; negative regulation of transforming growth factor beta receptor signaling pathway; proteolysis; SMAD protein complex assembly
Research Articles on ZFYVE9
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Product Notes
The Human ZFYVE9 zfyve9 (Catalog #AAA9322150) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9322150 ELISA Kit recognizes Human ZFYVE9. It is sometimes possible for the material contained within the vial of "zinc finger, FYVE domain containing 9, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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