Insulin-Like Growth Factor Binding Protein 2 Active Protein | IGFBP2 active protein

Insulin-Like Growth Factor Binding Protein 2, Recombinant, Human (IGFBP2, BP2, IBP2)

Cat. Num. AAA650079

• Gene Names: IGFBP2; IBP2; IGF-BP53
• Purity: Purified; Purified. 90% pure by SDS gel electrophoresis.
• Synonyms: Insulin-Like Growth Factor Binding Protein 2; Recombinant; Human (IGFBP2; BP2; IBP2); IGFBP2 active protein

• Host: Yeast
• Purity/Purification: Purified; Purified. 90% pure by SDS gel electrophoresis.
• Form/Format: Supplied as a lyophilized powder in PBS

• Biological Activity: Binding activity of human IGF-BP 2 is under investigation by the inhibition activity of both IGF I and II.
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Reconstitute to with sterile dH2O or buffer, aliquot and store at -20 degree C. Reconstituted product is stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for IGFBP2 active protein

The superfamily of insulin-like growth factor (IGF) binding proteins include the six high-affinity IGF binding proteins (IGFBP) and several low-affinity binding proteins referred to as IGFBP related proteins (IGFBP-rP). All IGFBP superfamily members are cysteine-rich proteins with conserved cysteine residues, which are clustered in the amino- and carboxy-terminal thirds of the molecule. IGFBPs modulate the biological activities of IGF proteins. Some IGFBPs may also have intrinsic bioactivity that is independent of their ability to bind IGF proteins. Post-translational modifications of IGFBP, including glycosylation, phosphorylation and proteolysis, have been shown to modify the affinities of the binding proteins to IGF.

Product Categories/Family for IGFBP2 active protein

Growth Factors; Cytokines; Growth Factors-IGF

NCBI and Uniprot Product Information

• NCBI GI #: 290457647
• NCBI GeneID: 3485
• UniProt Accession #: P18065; Q14619; Q9UCL3; Q59FF1
• Molecular Weight: 31kD
• NCBI Official Full Name: Insulin-like growth factor-binding protein 2
• NCBI Official Synonym Full Names: insulin-like growth factor binding protein 2, 36kDa
• NCBI Official Symbol: IGFBP2
• NCBI Official Synonym Symbols: IBP2; IGF-BP53
• NCBI Protein Information: insulin-like growth factor-binding protein 2; IBP-2; IGFBP-2; OTTHUMP00000207751; OTTHUMP00000207753; IGF-binding protein 2
• UniProt Protein Name: Insulin-like growth factor-binding protein 2
• Protein Family: Insulin-like growth factor-binding protein
• UniProt Gene Name: IGFBP2
• UniProt Synonym Gene Names: BP2; IBP2
• UniProt Entry Name: IBP2_HUMAN

Uniprot Description

Function: Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Ref.11

Subunit structure: Binds IGF2 more than IGF1.

Subcellular location: Secreted.

Domain: The C-terminus is required for IGF-binding and growth inhibition. Ref.11

Post-translational modification: O-glycosylated. Ref.10

Sequence similarities: Contains 1 IGFBP N-terminal domain.Contains 1 thyroglobulin type-1 domain.