Western Blot (WB)
Rabbit Phospho-CACNB2 Polyclonal Antibody | anti-CACNB2 antibody
Phospho CACNB2 Antibody
ELISA: 1:10,000
Western Blot: 1:500
Western Blot (WB)
Western Blot (WB)
The beta subunit of voltage-dependent calcium channel which contributes to calcium channel function by increasing peak calcium current, shifting the voltage dependencies fo activation and inactivation, modulating G-protein inhibition and controllin the alpha-1 subunit membrane targeting.
NCBI and Uniprot Product Information
NCBI Description
auxillary subunit of the L-type Ca(2+) channel [RGD, Feb 2006]
Uniprot Description
CACNB2: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Defects in CACNB2 are the cause of Brugada syndrome type 4 (BRGDA4). A heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Belongs to the calcium channel beta subunit family. 8 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, calcium
Cellular Component: sarcolemma; voltage-gated calcium channel complex
Molecular Function: actin filament binding; calcium channel regulator activity; high voltage-gated calcium channel activity; phosphoprotein binding; protein binding; protein domain specific binding; protein kinase binding; voltage-gated calcium channel activity
Biological Process: calcium ion transport; neuromuscular junction development; positive regulation of calcium ion transport; synaptic transmission; visual perception
Research Articles on CACNB2
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Product Notes
The CACNB2 cacnb2 (Catalog #AAA542597) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Phospho CACNB2 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Phospho-CACNB2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Dot Blot: 1:10,000 ELISA: 1:10,000 Western Blot: 1:500. Researchers should empirically determine the suitability of the CACNB2 cacnb2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Phospho-CACNB2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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