Human X-ray repair complementing defective repair in Chinese hamster cells 1 ELISA Kit | XRCC1 elisa kit
Human DNA repair protein XRCC1, XRCC1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]
Uniprot Description
XRCC1: Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF. Interacts with APEX1; the interaction is induced by SIRT1 and increases with the acetylated form of APEX1.
Protein type: DNA repair, damage
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding; enzyme binding; damaged DNA binding
Biological Process: single strand break repair; base-excision repair; DNA repair
Research Articles on XRCC1
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Product Notes
The Human XRCC1 xrcc1 (Catalog #AAA9334238) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9334238 ELISA Kit recognizes Human XRCC1. It is sometimes possible for the material contained within the vial of "X-ray repair complementing defective repair in Chinese hamster cells 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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