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Xaa-Pro Aminopeptidase P3/XPNPEP3 Recombinant Protein | XPNPEP3 recombinant protein

Recombinant Human Xaa-Pro Aminopeptidase P3/XPNPEP3 Protein (N, C-6His)

Gene Names
XPNPEP3; APP3; ICP55; NPHPL1
Purity
>95% as determined by reducing SDS-PAGE.
Synonyms
Xaa-Pro Aminopeptidase P3/XPNPEP3; Recombinant Human Xaa-Pro Aminopeptidase P3/XPNPEP3 Protein (N; C-6His); Probable Xaa-Pro Aminopeptidase 3; X-Pro Aminopeptidase 3; Aminopeptidase P3; APP3; XPNPEP3; XPNPEP3 recombinant protein
Ordering
For Research Use Only!
Host
E Coli
Purity/Purification
>95% as determined by reducing SDS-PAGE.
Form/Format
Supplied as a 0.2 mum filtered solution of 25mM Tris, 1mM DTT, pH 7.3.
Sequence Positions
Met1-Ser507
Sequence Length
507
Species
Human
Endotoxin
<1.0 EU per ug as determined by LAL test.
Fusion Tag
N, C-6His
Preparation and Storage
Store at < -20 degree C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
Related Product Information for XPNPEP3 recombinant protein
Probable Xaa-Pro Aminopeptidase 3 (XPNPEP3) is a member of the peptidase M24B family. XPNPEP3 has two isoforms and both are widely expressed. XPNPEP3 is localized in the Mitochondrion. XPNPEP3 catalyzes the release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide. Defects in XPNPEP3 are the cause of nephronophthisis-like nephropathy type 1 which is a disorder with features of nephronophthisis, a cystic kidney disease leading to end-stage renal failure.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
Molecular Mass: 60.2 kDa
Actual Protein Molecular Mass: 65 kDa
NCBI Official Full Name
xaa-Pro aminopeptidase 3 isoform 1
NCBI Official Synonym Full Names
X-prolyl aminopeptidase 3
NCBI Official Symbol
XPNPEP3
NCBI Official Synonym Symbols
APP3; ICP55; NPHPL1
NCBI Protein Information
xaa-Pro aminopeptidase 3
UniProt Protein Name
Xaa-Pro aminopeptidase 3
UniProt Gene Name
XPNPEP3
UniProt Synonym Gene Names
X-Pro aminopeptidase 3; APP3

NCBI Description

The protein encoded by this gene belongs to the family of X-pro-aminopeptidases that utilize a metal cofactor, and remove the N-terminal amino acid from peptides with a proline residue in the penultimate position. This protein has been shown to localize to the mitochondria of renal cells, and have a role in ciliary function. Mutations in this gene are associated with nephronophthisis-like nephropathy-1. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene, however, expression of some of these isoforms in vivo is not known.[provided by RefSeq, Mar 2011]

Uniprot Description

Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala (PubMed:25609706, PubMed:28476889). Also shows low activity towards peptides with Ala or Ser at the P1 position (PubMed:28476889).

Research Articles on XPNPEP3

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Product Notes

The XPNPEP3 xpnpep3 (Catalog #AAA2553389) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is Met1-Ser507. It is sometimes possible for the material contained within the vial of "Xaa-Pro Aminopeptidase P3/XPNPEP3, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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