Rat X-prolyl aminopeptidase (aminopeptidase P) 3, putative ELISA Kit | XPNPEP3 elisa kit
Rat Probable Xaa-Pro aminopeptidase 3, XPNPEP3 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
XPNPEP3: Defects in XPNPEP3 are the cause of nephronophthisis-like nephropathy type 1 (NPHPL1). A disorder with features of nephronophthisis, a cystic kidney disease leading to end-stage renal failure. Nephronophthisis is histologically characterized by modifications of the tubules with thickening of the basement membrane, interstitial fibrosis and, in the advanced stages, medullary cysts. Typical clinical manifestation are chronic renal failure, anemia, polyuria, polydipsia, isosthenuria, and growth retardation. Associations with extrarenal symptoms are frequent. In NPHPL1 patients, extrarenal symptoms include hypertension, essential tremor, sensorineural hearing loss and gout. Severely affected individuals can manifest a mitochondrial disorder with isolated complex I deficiency activity in muscle, seizures, mental retardation and hypertrophic dilated cardiomyopathy. Belongs to the peptidase M24B family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.11.9; Protease
Cellular Component: mitochondrion
Molecular Function: manganese ion binding; aminopeptidase activity
Biological Process: glomerular filtration; protein processing; proteolysis
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Product Notes
The Rat XPNPEP3 xpnpep3 (Catalog #AAA9339767) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9339767 ELISA Kit recognizes Rat XPNPEP3. It is sometimes possible for the material contained within the vial of "X-prolyl aminopeptidase (aminopeptidase P) 3, putative, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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