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SDS-Page

Xeroderma Pigmentosum, Complementation Group D Recombinant Protein | XPD recombinant protein

Recombinant Xeroderma Pigmentosum, Complementation Group D (XPD)

Gene Names
XPC; XP3; RAD4; XPCC; p125
Applications
SDS-Page, Western Blot
Purity
> 97%
Synonyms
Xeroderma Pigmentosum; Complementation Group D; Recombinant Xeroderma Pigmentosum; Complementation Group D (XPD); CXPD; BTF2 p80; EM9; TTD; ERCC2; TFIIH basal transcription factor complex 80 kDa; De Sanctis-Cacchione; Excision Repair Cross-Complementing Rodent Repair Deficiency 2; XPD recombinant protein
Ordering
For Research Use Only!
Host
E.coli
Purity/Purification
> 97%
Form/Format
Freeze-dried powder; 20mM Tris, 150mM NaCl, pH8.0, containing 0.01% SKL, 5% Trehalose
Concentration
Original Concentration: 150ug/mL (varies by lot)
Sequence
ATLVSTY AKGFTIIIEP FDDRTPTIAN PILHFSCMDA SLAIKPVFER FQSVIITSGT LSPLDIYPKI LDFHPVTMAT FTMTLARVCL CPMIIGRGND QVAISSKFET REDIAVIRNY GNLLLEMSAV VPDGIVAFFT SYQYMESTVA SWYEQGILEN IQRNKLLFIE TQDGAETSVA LEKYQEACENGRGAILLSVA RGKVSEGIDF VHHYGRAVIM FGVPYVYTQS RILKARL
Applicable Applications for XPD recombinant protein
Positive Control; Immunogen; SDS-PAGE (SDS); Western Blot (WB)
Application Notes
May be suitable for use in other assays to be determined by the end user.
Organism Species
Homo sapiens (Human)
Source
Prokaryotic expression
Residues
Ala404~Leu637
Tags
N-terminal His Tag
Subcellular Location
Nucleus, Cytoplasm
Predicted isoelectric point
5.6
Usage
Reconstitute in ddH2O to a concentration of 0-0.05 mg/mL. Do not vortex.
Preparation and Storage
Storage:
Avoid repeated freeze/thaw cycles.
Store at 2-8ºC for one month.
Aliquot and store at -80ºC for 12 months.

Stability Test:
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

SDS-Page

SDS-Page

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Official Full Name
Xeroderma pigmentosum, complementation group C
NCBI Official Synonym Full Names
xeroderma pigmentosum, complementation group C
NCBI Official Symbol
XPC
NCBI Official Synonym Symbols
XP3; RAD4; XPCC; p125
NCBI Protein Information
DNA repair protein complementing XP-C cells
UniProt Protein Name
DNA repair protein complementing XP-C cells
Protein Family
UniProt Gene Name
XPC
UniProt Synonym Gene Names
XPCC
UniProt Entry Name
XPC_HUMAN

NCBI Description

This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]

Uniprot Description

XPC: a probable nuclear protein involved in DNA excision repair. May play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes. Defects in XPC are a cause of xeroderma pigmentosum complementation group C.

Protein type: DNA repair, damage

Chromosomal Location of Human Ortholog: 3p25.1

Cellular Component: cytoplasm; nucleolus; nucleoplasm; nucleus; plasma membrane

Molecular Function: bubble DNA binding; damaged DNA binding; loop DNA binding; protein binding; single-stranded DNA binding

Biological Process: cellular protein metabolic process; DNA repair; intra-S DNA damage checkpoint; mismatch repair; nucleotide-excision repair; nucleotide-excision repair, DNA damage recognition; post-translational protein modification; protein sumoylation; response to drug; response to UV-B

Disease: Xeroderma Pigmentosum, Complementation Group C

Research Articles on XPD

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Product Notes

The XPD xpc (Catalog #AAA2033167) is a Recombinant Protein produced from E.coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Xeroderma Pigmentosum, Complementation Group D can be used in a range of immunoassay formats including, but not limited to, Positive Control; Immunogen; SDS-PAGE (SDS); Western Blot (WB). May be suitable for use in other assays to be determined by the end user. Researchers should empirically determine the suitability of the XPD xpc for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: ATLVSTY AKGFTIIIEP FDDRTPTIAN PILHFSCMDA SLAIKPVFER FQSVIITSGT LSPLDIYPKI LDFHPVTMAT FTMTLARVCL CPMIIGRGND QVAISSKFET REDIAVIRNY GNLLLEMSAV VPDGIVAFFT SYQYMESTVA SWYEQGILEN IQRNKLLFIE TQDGAETSVA LEKYQEACEN GRGAILLSVA RGKVSEGIDF VHHYGRAVIM FGVPYVYTQS RILKARL. It is sometimes possible for the material contained within the vial of "Xeroderma Pigmentosum, Complementation Group D, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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