Platelet Derived Growth Factor B (PDGF-B) Western Blot Control | PDGF-B western blot control

Platelet Derived Growth Factor B (PDGF-B) (Western Blot Control)

Cat. Num. AAA343111

• Gene Names: PDGFB; SIS; SSV; IBGC5; PDGF2; c-sis; PDGF-2
• Purity: >= 95% (SDS PAGE)
• Synonyms: Platelet Derived Growth Factor B (PDGF-B); Platelet Derived Growth Factor B (PDGF-B) (Western Blot Control); PDGF-B; Platelet derived growth factor B; PDGF2; SIS; SSV; c-SIS; becaplermin; v-SIS; PDGF-B western blot control

• Purity/Purification: >= 95% (SDS PAGE)
• Form/Format: Liquid
• Sequence Length: 241

• Buffer: Buffered 50% glycerol

Related Product Information for PDGF-B western blot control

The term PDGF refers to a family of disulphide bondlinked dimeric isoforms that act as autocrine and paracrine growth factors and are produced by a variety of cell types other than platelets. They act as potent mitogens for almost all mesenchymally-derived cells. Aberrant expression is involved in certain cancers, fibroproliferative disorders and atherosclerosis. The protein also contributes to wound healing and neural regeneration. There are four members of the PDGF family; PDGF A, PDGF B, PDGF C and PDGF D. Two distinct types of PDGF-A exist; a short form that is soluble and a long form that is retained by the extracellular matrix. Recombinant PDGF-A comprises a 110 amino acid fragment (87-196) corresponding to the mature PDGF-A short chain protein and is expressed in E Coli with an amino-terminal hexahistidine tag. This product is not intended for therapeutic use

Product Categories/Family for PDGF-B western blot control

Recombinant Proteins; Platelet Derived Growth Factor B Chain

References

Raines, E.W. & Ross, R. (1982) J. Biol. Chem. 257(9): 5154-5160. Heldin, C.H. (1992) EMBO J. 11(12): 4251-4259.

NCBI and Uniprot Product Information

• NCBI GI #: 4505681
• NCBI GeneID: 5155
• NCBI Accession #: NP_002599.1
• NCBI GenBank Nucleotide #: NM_002608.3
• UniProt Accession #: P01127; P78431; Q15354; Q6FHE7; Q9UF23; G3XAG8
• Molecular Weight: 25,502 Da
• NCBI Official Full Name: platelet-derived growth factor subunit B isoform 1 preproprotein
• NCBI Official Synonym Full Names: platelet derived growth factor subunit B
• NCBI Official Symbol: PDGFB
• NCBI Official Synonym Symbols: SIS; SSV; IBGC5; PDGF2; c-sis; PDGF-2
• NCBI Protein Information: platelet-derived growth factor subunit B
• UniProt Protein Name: Platelet-derived growth factor subunit B
• UniProt Gene Name: PDGFB
• UniProt Synonym Gene Names: PDGF2; SIS; PDGF subunit B
• UniProt Entry Name: PDGFB_HUMAN

NCBI Description

This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

Uniprot Description

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin (PubMed:26599395). Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA ().