Mouse Vitamin K epoxide reductase complex subunit 1 ELISA Kit | Vkorc1 elisa kit

Mouse Vitamin K epoxide reductase complex subunit 1 ELISA Kit

Cat. Num. AAA2882471

• Gene Names: Vkorc1; D7Wsu86e
• Reactivity: Mouse
• Synonyms: Vitamin K epoxide reductase complex subunit 1; Mouse Vitamin K epoxide reductase complex subunit 1 ELISA Kit; Vitamin K1 2; 3-epoxide reductase subunit 1; Vkorc1; 1.1.4.1; Vkorc1 elisa kit

• Reactivity: Mouse
• Sequence Length: 161

• Assay Type: Sandwich
• Detection Range: 0.312-20 ng/mL
• Sensitivity: 0.171 ng/mL
• Intra-Assay CV: <=5.5%
• Inter-Assay CV: <=8.2%
• Recovery: 104%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 30519915
• NCBI GeneID: 27973
• NCBI Accession #: NP_848715.1
• NCBI GenBank Nucleotide #: NM_178600.2
• UniProt Accession #: Q9CRC0
• Molecular Weight: 17,768 Da
• NCBI Official Full Name: vitamin K epoxide reductase complex subunit 1
• NCBI Official Synonym Full Names: vitamin K epoxide reductase complex, subunit 1
• NCBI Official Symbol: Vkorc1
• NCBI Official Synonym Symbols: D7Wsu86e
• NCBI Protein Information: vitamin K epoxide reductase complex subunit 1
• UniProt Protein Name: Vitamin K epoxide reductase complex subunit 1
• Protein Family: Vitamin K epoxide reductase complex
• UniProt Gene Name: Vkorc1
• UniProt Entry Name: VKOR1_MOUSE

NCBI Description

Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. [provided by RefSeq, Jul 2008]

Uniprot Description

VKORC1: Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Defects in VKORC1 are a cause of combined deficiency of vitamin K-dependent clotting factors type 2 (VKCFD2). VKCFD leads to a bleeding tendency that is usually reversed by oral administration of vitamin K. Defects in VKORC1 are a cause of coumarin resistance (CMRES). A condition characterized by partial or complete resistance to warfarin or other 4-hydroxycoumarin derivatives. These drugs are used as anti-coagulants for the prevention of thromboembolic diseases in subjects with deep vein thrombosis, atrial fibrillation, or mechanical heart valve replacement. Belongs to the VKOR family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; EC 1.1.4.1; Oxidoreductase; Membrane protein, integral; Endoplasmic reticulum

Cellular Component: endoplasmic reticulum; integral to membrane; intracellular membrane-bound organelle; membrane

Molecular Function: oxidoreductase activity; quinone binding; vitamin-K-epoxide reductase (warfarin-insensitive) activity; vitamin-K-epoxide reductase (warfarin-sensitive) activity

Biological Process: blood coagulation; drug metabolic process; peptidyl-glutamic acid carboxylation; positive regulation of coagulation; regulation of blood coagulation; response to antibiotic; response to organic cyclic substance; response to organic nitrogen; vitamin K biosynthetic process; vitamin K metabolic process