Human Vitamin K epoxide reductase complex subunit 1 ELISA Kit | VKORC1 elisa kit
Human Vitamin K epoxide reductase complex subunit 1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
VKORC1: Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Defects in VKORC1 are a cause of combined deficiency of vitamin K-dependent clotting factors type 2 (VKCFD2). VKCFD leads to a bleeding tendency that is usually reversed by oral administration of vitamin K. Defects in VKORC1 are a cause of coumarin resistance (CMRES). A condition characterized by partial or complete resistance to warfarin or other 4-hydroxycoumarin derivatives. These drugs are used as anti-coagulants for the prevention of thromboembolic diseases in subjects with deep vein thrombosis, atrial fibrillation, or mechanical heart valve replacement. Belongs to the VKOR family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.1.4.1; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: endoplasmic reticulum membrane
Molecular Function: vitamin-K-epoxide reductase (warfarin-sensitive) activity
Biological Process: blood coagulation; drug metabolic process; peptidyl-glutamic acid carboxylation; vitamin K metabolic process
Disease: Coumarin Resistance; Vitamin K-dependent Clotting Factors, Combined Deficiency Of, 2
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Product Notes
The Human VKORC1 vkorc1 (Catalog #AAA9425703) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9425703 ELISA Kit recognizes Human VKORC1. It is sometimes possible for the material contained within the vial of "Vitamin K epoxide reductase complex subunit 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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