Mouse vang-like 2 (van gogh, Drosophila) ELISA Kit | VANGL2 elisa kit

Mouse Vang-like protein 2, VANGL2 ELISA Kit

Cat. Num. AAA9322065

• Gene Names: Vangl2; Lp; Lpp1; Ltap; stbm; ska17; Vang1l2; loop-tail; strabismus; ska<m17Jus>; C530001F03Rik
• Reactivity: Mouse
• Synonyms: vang-like 2 (van gogh; Drosophila); Mouse Vang-like protein 2; VANGL2 ELISA Kit; Mouse Vang-like protein 2 (VANGL2) ELISA kit; KIAA1215; LPP1; LTAP; MGC119403; MGC119404; STB1; STBM; STBM1; loop-tail-associated protein; strabismus; vang; van gogh-like 2; vang-like 2; VANGL2 elisa kit

• Reactivity: Mouse

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 15723382
• NCBI GeneID: 93840
• NCBI Accession #: NP_277044.1
• NCBI GenBank Nucleotide #: NM_033509.3
• UniProt Accession #: Q91ZD4; Q923Z8
• Molecular Weight: 59,771 Da
• NCBI Official Full Name: vang-like protein 2
• NCBI Official Synonym Full Names: vang-like 2 (van gogh, Drosophila)
• NCBI Official Symbol: Vangl2
• NCBI Official Synonym Symbols: Lp; Lpp1; Ltap; stbm; ska17; Vang1l2; loop-tail; strabismus; ska<m17Jus>; C530001F03Rik
• NCBI Protein Information: vang-like protein 2; loop-tail protein 1; vang (van gogh)-like 2; van Gogh-like protein 2; loop tail associated protein; loop-tail-associated protein
• UniProt Protein Name: Vang-like protein 2
• Protein Family: Vang-like protein
• UniProt Gene Name: Vangl2
• UniProt Synonym Gene Names: Lpp1; Ltap
• UniProt Entry Name: VANG2_MOUSE

Uniprot Description

VANGL2: Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Interacts through its C-terminal region with the N- terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction. Also interacts with the PDZ domains of MAGI3, SCRIB/SCRB1 and FZD3. Belongs to the Vang family.

Protein type: Adaptor/scaffold; Membrane protein, multi-pass; Membrane protein, integral

Cellular Component: membrane; basolateral plasma membrane; apical plasma membrane; plasma membrane; integral to membrane; stress fiber; intracellular; intercellular junction; ER to Golgi transport vesicle; lateral plasma membrane

Molecular Function: protein binding

Biological Process: positive regulation of JNK activity; convergent extension involved in axis elongation; wound healing; somatic stem cell maintenance; multicellular organismal development; glomerulus development; Rho protein signal transduction; anterior/posterior pattern formation; apical protein localization; hair follicle development; sensory cilium biogenesis; somatic stem cell division; establishment of planar polarity; heart looping; Wnt receptor signaling pathway, planar cell polarity pathway; inner ear receptor cell development; convergent extension involved in neural plate elongation; regulation of Wnt receptor signaling pathway; digestive tract morphogenesis; patterning of blood vessels; establishment and/or maintenance of epithelial cell polarity; inner ear receptor stereocilium organization and biogenesis; convergent extension involved in organogenesis; regulation of actin cytoskeleton organization and biogenesis; establishment of body hair orientation; neural tube closure