Human Vang-like protein 2 ELISA Kit | VANGL2 elisa kit

Human Vang-like protein 2 ELISA Kit

Cat. Num. AAA2888250

• Gene Names: VANGL2; LPP1; LTAP; STB1; STBM; STBM1
• Reactivity: Human
• Synonyms: Vang-like protein 2; Human Vang-like protein 2 ELISA Kit; VANGL2 elisa kit

• Reactivity: Human
• Sequence Length: 521

• Assay Type: Sandwich
• Detection Range: 0.312-20 ng/mL
• Sensitivity: 0.194 ng/mL
• Intra-Assay CV: <=5.5%
• Inter-Assay CV: <=6.8%
• Recovery: 98%

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 62955805
• NCBI GeneID: 57216
• NCBI Accession #: NP_065068.1
• NCBI GenBank Nucleotide #: NM_020335.2
• UniProt Accession #: Q9ULK5; Q5T212; D3DVE9
• Molecular Weight: 59,714 Da
• NCBI Official Full Name: vang-like protein 2
• NCBI Official Synonym Full Names: VANGL planar cell polarity protein 2
• NCBI Official Symbol: VANGL2
• NCBI Official Synonym Symbols: LPP1; LTAP; STB1; STBM; STBM1
• NCBI Protein Information: vang-like protein 2
• UniProt Protein Name: Vang-like protein 2
• Protein Family: Vang-like protein
• UniProt Gene Name: VANGL2
• UniProt Synonym Gene Names: KIAA1215; STB1

NCBI Description

The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. [provided by RefSeq, Sep 2011]

Uniprot Description

VANGL2: Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Interacts through its C-terminal region with the N- terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction. Also interacts with the PDZ domains of MAGI3, SCRIB/SCRB1 and FZD3. Belongs to the Vang family.

Protein type: Adaptor/scaffold; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1q23.2

Cellular Component: apical plasma membrane; basolateral plasma membrane; COPII-coated ER to Golgi transport vesicle; integral component of membrane; intercellular junction; lateral plasma membrane; plasma membrane; stress fiber

Molecular Function: protein binding

Biological Process: anterior/posterior pattern specification; apical protein localization; cochlea morphogenesis; convergent extension involved in axis elongation; convergent extension involved in neural plate elongation; digestive tract morphogenesis; dopaminergic neuron axon guidance; establishment of body hair orientation; establishment of planar polarity; establishment of planar polarity involved in neural tube closure; establishment or maintenance of epithelial cell apical/basal polarity; glomerulus development; hair follicle development; heart looping; heparan sulfate proteoglycan biosynthetic process; inner ear receptor stereocilium organization and biogenesis; membranous septum morphogenesis; muscular septum morphogenesis; neural tube closure; non-motile cilium assembly; planar cell polarity pathway involved in axis elongation; planar cell polarity pathway involved in axon guidance; planar cell polarity pathway involved in neural tube closure; positive regulation of JUN kinase activity; regulation of actin cytoskeleton organization; regulation of Wnt receptor signaling pathway; Rho protein signal transduction; serotonergic neuron axon guidance; somatic stem cell division; somatic stem cell maintenance; wound healing

Disease: Neural Tube Defects