uXT recombinant protein

uXT, 1-157aa, Human, His tag, E Coli (Denatured)

Cat. Num. AAA204861

• Gene Names: UXT; STAP1; ART-27
• Applications: SDS-Page
• Purity: > 90% by SDS-PAGE
• Synonyms: uXT; 1-157aa; Human; His tag; E Coli (Denatured); Protein uXT; ART-27; STAP1; uXT recombinant protein

• Host: E Coli
• Purity/Purification: > 90% by SDS-PAGE
• Form/Format: Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.4M urea, 10% glycerol
• Concentration: 1 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MGSSHHHHHH SSGLVPRGSH MATPPKRRAV EATGEKVLRY ETFISDVLQR DLRKVLDHRD KVYEQLAKYL QLRNVIERLQ EAKHSELYMQ VDLGCNFFVD TVVPDTSRIY VALGYGFFLE LTLAEALKFI DRKSSLLTEL SNSLTKDSMN IKAHIHMLLE GLRELQGLQN FPEKPHH
• Sequence Length: 157

• Applicable Applications for uXT recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for uXT recombinant protein

ubiquitously-expressed transcript, also known as uXT, belongs to the uXT family. This protein functions as a cofactor that modulates androgen receptor-dependent transcription, and also plays a critical role in tumor necrosis factor-induced apoptosis. Expression of this gene may play a role in tumorigenesis. Recombinant human uXT protein, fused to His-tag at N-terminus, was expressed in E Coli.

Product Categories/Family for uXT recombinant protein

Epigenomics

References

Markus S.M., et al. (2002) Mol. Biol. Cell. 13:670-682; Sun S., et al. (2007) J. Cell Biol. 178:231-244;

NCBI and Uniprot Product Information

• NCBI GI #: 4759298
• NCBI GeneID: 8409
• NCBI Accession #: NP_004173
• NCBI GenBank Nucleotide #: NM_004182.3
• UniProt Accession #: Q9UBK9; Q5JZG3; Q9Y6E5; A0A0C4DFR8; B2R561
• Molecular Weight: 20.4 kDa (177aa)
• NCBI Official Full Name: protein UXT isoform 2
• NCBI Official Synonym Full Names: ubiquitously expressed prefoldin like chaperone
• NCBI Official Symbol: UXT
• NCBI Official Synonym Symbols: STAP1; ART-27
• NCBI Protein Information: protein UXT
• UniProt Protein Name: Protein UXT
• Protein Family: Protein
• UniProt Gene Name: UXT
• UniProt Synonym Gene Names: ART-27

NCBI Description

The protein encoded by this gene functions as a cofactor that modulates androgen receptor-dependent transcription, and also plays a critical role in tumor necrosis factor-induced apoptosis. Expression of this gene may play a role in tumorigenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Uniprot Description

Involved in gene transcription regulation (PubMed:28106301, PubMed:21730289). Acts in concert with the corepressor URI1 to regulate androgen receptor AR-mediated transcription (PubMed:11854421, PubMed:21730289). Together with URI1, associates with chromatin to the NKX3-1 promoter region (PubMed:21730289). Negatively regulates the transcriptional activity of the estrogen receptor ESR1 by inducing its translocation into the cytoplasm (PubMed:28106301). May act as nuclear chaperone that facilitates the formation of the NF-kappa-B enhanceosome and thus positively regulates NF-kappa-B transcription activity (PubMed:17620405, PubMed:21307340). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:17554592). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584).