Utrophin (UTRN) Recombinant Protein | UTRN recombinant protein

Recombinant Human Utrophin (UTRN) , partial

Cat. Num. AAA966979

• Gene Names: UTRN; DRP; DMDL; DRP1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Utrophin (UTRN); Recombinant Human Utrophin (UTRN); partial; UTRN recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,347

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for UTRN recombinant protein

This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. This protein is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined.

NCBI and Uniprot Product Information

• NCBI GI #: 110611228
• NCBI GeneID: 7402
• NCBI Accession #: NP_009055.2
• NCBI GenBank Nucleotide #: NM_007124.2
• UniProt Accession #: P46939; Q5SYY1; Q5SZ57; Q9UJ40
• Molecular Weight: 155,026 Da
• NCBI Official Full Name: utrophin
• NCBI Official Synonym Full Names: utrophin
• NCBI Official Symbol: UTRN
• NCBI Official Synonym Symbols: DRP; DMDL; DRP1
• NCBI Protein Information: utrophin
• UniProt Protein Name: Utrophin
• Protein Family: Utrophin
• UniProt Gene Name: UTRN
• UniProt Synonym Gene Names: DMDL; DRP1; DRP-1

NCBI Description

This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

May play a role in anchoring the cytoskeleton to the plasma membrane.