NCBI and Uniprot Product Information
NCBI Description
This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
Uniprot Description
utrophin: May play a role in anchoring the cytoskeleton to the plasma membrane.
Protein type: Motility/polarity/chemotaxis; Dystrophin complex
Chromosomal Location of Human Ortholog: 6q24
Cellular Component: dystrophin-associated glycoprotein complex; nucleoplasm; filopodium membrane; postsynaptic membrane; cytoskeleton; protein complex; membrane; cytoplasm; plasma membrane; cell junction; neuromuscular junction; filopodium
Molecular Function: integrin binding; protein binding; zinc ion binding; actin binding; protein kinase binding; vinculin binding
Biological Process: muscle development; muscle contraction; positive regulation of cell-matrix adhesion
Research Articles on UTRN
Similar Products
Product Notes
The Monkey UTRN utrn (Catalog #AAA744992) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA744992 ELISA Kit recognizes Monkey UTRN. It is sometimes possible for the material contained within the vial of "Utrophin, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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