Ubiquitin carboxyl-terminal hydrolase 8 (Usp8) Recombinant Protein | Usp8 recombinant protein

Recombinant Mouse Ubiquitin carboxyl-terminal hydrolase 8 (Usp8) , partial

• Gene Names: Usp8; Ubpy; AI574262; AW557536; mKIAA0055
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Ubiquitin carboxyl-terminal hydrolase 8 (Usp8); Recombinant Mouse Ubiquitin carboxyl-terminal hydrolase 8 (Usp8); partial; Usp8 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1080

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 31981044
• NCBI GeneID: 84092
• NCBI Accession #: NP_062703.2
• NCBI GenBank Nucleotide #: NM_019729.3
• UniProt Accession #: Q80U87; Q80YP2; Q8R0D3; Q9EQU1; Q9WVP5; A2AI53
• Molecular Weight: 122,611 Da
• NCBI Official Full Name: ubiquitin carboxyl-terminal hydrolase 8 isoform 2
• NCBI Official Synonym Full Names: ubiquitin specific peptidase 8
• NCBI Official Symbol: Usp8
• NCBI Official Synonym Symbols: Ubpy; AI574262; AW557536; mKIAA0055
• NCBI Protein Information: ubiquitin carboxyl-terminal hydrolase 8
• UniProt Protein Name: Ubiquitin carboxyl-terminal hydrolase 8
• UniProt Gene Name: Usp8
• UniProt Synonym Gene Names: Kiaa0055; Ubpy; mUBPy

Uniprot Description

Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1 ().