Follicle Stimulating Hormone Native Protein | FSH native protein

Human Follicle Stimulating Hormone

Cat. Num. AAA142643

• Synonyms: Follicle Stimulating Hormone; Human Follicle Stimulating Hormone; FSH Human; Follitropin subunit beta; Follicle-stimulating hormone beta subunit; FSH-beta; FSH-B; Follitropin beta chain; FSH; FSH native protein

• Host: Urine of post-menopausal women
• Form/Format: The FSH was lyophilized with no additives.; Sterile Filtered White lyophilized (freeze-dried) powder.
• Sequence Length: 129

• Contaminents: Less than: 0.1% hCG, 0.5%TSH, 0.5% LH, 0.5%GH and 0.5%Prl.Free of HbsAg, antibodies to HIV and HCV.
• Solubility: It is recommended to reconstitute the lyophilized Follicle Stimulating Hormone in sterile pyrogen free water at 100IU/0.1ml, which can then be further diluted to other aqueous solutions.
• Preparation and Storage: Lyophilized FSH although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution FSH-beta should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Related Product Information for FSH native protein

Description: FSH Human is a glycoprotein produced from urine of post-menopausal women and having a total molecular mass of 30,000 Dalton.FSH is a heterodimeric hormone consisting of 92 amino acids a chain and 111 amino acids b chain.The FSH is purified by proprietary chromatographic techniques.

Introduction: Follicle stimulating hormone (FSH) is a hormone synthesised and secreted by gonadotropes in the anterior pituitary gland. FSH and LH act synergistically in reproductionIn women, in the ovary FSH stimulates the growth of immature Graafian follicles to maturation. As the follicle grows it releases inhibin, which shuts off the FSH production. In men, FSH enhances the production of androgen-binding proteinby the Sertoli cells of the testes and is critical for spermatogenesis. In both males and females, FSH stimulates the maturation of germ cells. In females, FSH initiates follicular growth, specifically affecting granulosa cells. With the concomitant rise in inhibin B FSH levels then decline in the late follicular phase. This seems to be critical in selecting only the most advanced follicle to proceed to ovulation. At the end of the luteal phase, there is a slight rise in FSH that seems to be of importance to start the next ovulatory cycle.Like its partner, LH, FSH release at the pituitary gland is controlled by pulses of gonadotropin-releasing hormone(GnRH). Those pulses, in turn, are subject to the estrogen feed-back from the gonads.

Product Categories/Family for FSH native protein

Hormones; Hormones; FSH

NCBI and Uniprot Product Information

• NCBI GI #: 4503791
• NCBI GeneID: 2488
• NCBI Accession #: NP_000501.1
• NCBI GenBank Nucleotide #: NM_000510.2
• UniProt Accession #: P01225; Q14D61; A2TF08; A5JVV3
• Molecular Weight: 14,700 Da
• NCBI Official Full Name: follitropin subunit beta
• NCBI Official Synonym Full Names: follicle stimulating hormone, beta polypeptide
• NCBI Official Symbol: FSHB
• NCBI Protein Information: follitropin subunit beta; FSH-B; FSH-beta; follicle-stimulating hormone beta subunit; follitropin beta chain; follitropin, beta chain
• UniProt Protein Name: Follitropin subunit beta
• UniProt Gene Name: FSHB
• UniProt Synonym Gene Names: FSH-B; FSH-beta
• UniProt Entry Name: FSHB_HUMAN

NCBI Description

The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Uniprot Description

FSHB: Stimulates development of follicle and spermatogenesis in the reproductive organs. Defects in FSHB are a cause of isolated follicle- stimulating hormone deficiency (IFSHD). Selective follicle-stimulating hormone deficiency is an uncommon cause of infertility, producing amenorrhea and hypogonadism in women and oligo or azoospermia with normal testosterone levels in normally virilised men. Belongs to the glycoprotein hormones subunit beta family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11p13

Cellular Component: cytoplasm; extracellular region

Molecular Function: follicle-stimulating hormone activity; protein binding; hormone activity

Biological Process: progesterone biosynthetic process; follicle-stimulating hormone signaling pathway; peptide hormone processing; female gamete generation; Sertoli cell proliferation; female pregnancy; signal transduction; cellular protein metabolic process; regulation of osteoclast differentiation; transforming growth factor beta receptor signaling pathway; positive regulation of cell proliferation; positive regulation of bone resorption; positive regulation of transcription from RNA polymerase II promoter; positive regulation of cell migration

Disease: Follicle-stimulating Hormone Deficiency, Isolated