UDP-glucuronosyltransferase 1-4 Recombinant Protein | UGT1A4 recombinant protein
UDP-glucuronosyltransferase 1-4
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins. [provided by RefSeq, Jul 2008]
Uniprot Description
UGT1A4: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Defects in UGT1A4 are the cause of Gilbert syndrome (GILBS). Gilbert syndrome occurs as a consequence of reduced bilirubin transferase activity and is often detected in young adults with vague nonspecific complaints. Defects in UGT1A4 are the cause of Crigler-Najjar syndrome type 1 (CN1). CN1 patients have severe hyperbilirubinemia and usually die of kernicterus (bilirubin accumulation in the basal ganglia and brainstem nuclei) within the first year of life. CN1 inheritance is autosomal recessive. Defects in UGT1A4 are the cause of Crigler-Najjar syndrome type 2 (CN2). CN2 patients have less severe hyperbilirubinemia and usually survive into adulthood without neurologic damage. Phenobarbital, which induces the partially deficient glucuronyl transferase, can diminish the jaundice. CN2 inheritance is autosomal dominant. Belongs to the UDP-glycosyltransferase family. 1 isoforms of the human protein are produced by alternative splicing.
Protein type: Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Carbohydrate Metabolism - pentose and glucuronate interconversions; EC 2.4.1.17; Lipid Metabolism - androgen and estrogen; Xenobiotic Metabolism - metabolism by cytochrome P450; Carbohydrate Metabolism - starch and sucrose; Carbohydrate Metabolism - ascorbate and aldarate; Transferase; Xenobiotic Metabolism - drug metabolism - other enzymes; Endoplasmic reticulum; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Cofactor and Vitamin Metabolism - retinol; Membrane protein, integral
Chromosomal Location of Human Ortholog: 2q37
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane
Molecular Function: glucuronosyltransferase activity; protein heterodimerization activity; protein homodimerization activity; retinoic acid binding
Biological Process: bilirubin conjugation; flavonoid biosynthetic process; heme catabolic process
Disease: Crigler-najjar Syndrome, Type I; Gilbert Syndrome
Research Articles on UGT1A4
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Product Notes
The UGT1A4 ugt1a4 (Catalog #AAA7043534) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 29-534aa; full length protein. The amino acid sequence is listed below: GKVLVVPTDG SPWLSMREAL RELHARGHQA VVLTPEVNMH IKEEKFFTLT AYAVPWTQKE FDRVTLGYTQ GFFETEHLLK RYSRSMAIMN NVSLALHRCC VELLHNEALI RHLNATSFDV VLTDPVNLCG AVLAKYLSIP AVFFWRYIPC DLDFKGTQCP NPSSYIPKLL TTNSDHMTFL QRVKNMLYPL ALSYICHTFS APYASLASEL FQREVSVVDL VSYASVWLFR GDFVMDYPRP IMPNMVFIGG INCANGKPLS QEFEAYINAS GEHGIVVFSL GSMVSEIPEK KAMAIADALG KIPQTVLWRY TGTRPSNLAN NTILVKWLPQ NDLLGHPMTR AFITHAGSHG VYESICNGVP MVMMPLFGDQ MDNAKRMETK GAGVTLNVLE MTSEDLENAL KAVINDKSYK ENIMRLSSLH KDRPVEPLDL AVFWVEFVMR HKGAPHLRPA AHDLTWYQYH SLDVIGFLLA VVLTVAFITF KCCAYGYRKC LGKKGRVKKA HKSKTH. It is sometimes possible for the material contained within the vial of "UDP-glucuronosyltransferase 1-4, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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