Ubiquitin fusion degradation protein 1 homolog (UFD1L) Recombinant Protein | UFD1L recombinant protein

Recombinant Human Ubiquitin fusion degradation protein 1 homolog (UFD1L)

Cat. Num. AAA1307661

• Gene Names: UFD1L; UFD1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Ubiquitin fusion degradation protein 1 homolog (UFD1L); Recombinant Human Ubiquitin fusion degradation protein 1 homolog (UFD1L); Ubiquitin fusion degradation protein 1 homolog; UB fusion protein 1; UFD1L recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-307aa; Full Length
• Sequence: MFSFNMFDHPIPRVFQNRFSTQYRCFSVSMLAGPNDRSDVEKGGKIIMPPSALDQLSRLNITYPMLFKLTNKNSDRMTHCGVLEFVADEGICYLPHWMMQNLLLEEGGLVQVESVNLQVATYSKFQPQSPDFLDITNPKAVLENALRNFACLTTGDVIAINYNEKIYELRVMETKPDKAVSIIECDMNVDFDAPLGYKEPERQVQHEESTEGEADHSGYAGELGFRAFSGSGNRLDGKKKGVEPSPSPIKPGDIKRGIPNYEFKLGKITFIRNSRPLVKKVEEDEAGGRFVAFSGEGQSLRKKGRKP
• Sequence Length: 307

• Species: Homo sapiens (Human)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

SDS-PAGE

Related Product Information for UFD1L recombinant protein

Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures.

Product Categories/Family for UFD1L recombinant protein

Cell Biology

NCBI and Uniprot Product Information

• NCBI GI #: 241982785
• NCBI GeneID: 7353
• NCBI Accession #: NP_001030324.2
• NCBI GenBank Nucleotide #: NM_001035247.2
• UniProt Accession #: Q92890; Q9Y5N0; A8MW31
• Molecular Weight: 61.5 kDa
• NCBI Official Full Name: ubiquitin fusion degradation protein 1 homolog isoform B
• NCBI Official Synonym Full Names: ubiquitin fusion degradation 1 like (yeast)
• NCBI Official Symbol: UFD1L
• NCBI Official Synonym Symbols: UFD1
• NCBI Protein Information: ubiquitin fusion degradation protein 1 homolog; UB fusion protein 1
• UniProt Protein Name: Ubiquitin fusion degradation protein 1 homolog
• UniProt Gene Name: UFD1L
• UniProt Synonym Gene Names: UB fusion protein 1
• UniProt Entry Name: UFD1_HUMAN

NCBI Description

The protein encoded by this gene forms a complex with two other proteins, nuclear protein localization-4 and valosin-containing protein, and this complex is necessary for the degradation of ubiquitinated proteins. In addition, this complex controls the disassembly of the mitotic spindle and the formation of a closed nuclear envelope after mitosis. Mutations in this gene have been associated with Catch 22 syndrome as well as cardiac and craniofacial defects. Alternative splicing results in multiple transcript variants encoding different isoforms. A related pseudogene has been identified on chromosome 18. [provided by RefSeq, Jun 2009]

Uniprot Description

UFD1L: Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures. Belongs to the UFD1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin-specific protease; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: nucleus; cytosol

Molecular Function: protein binding; ubiquitin-specific protease activity; protein complex binding; receptor binding

Biological Process: ubiquitin-dependent protein catabolic process; proteasomal ubiquitin-dependent protein catabolic process; skeletal development