Rabbit UFD1L Monoclonal Antibody | anti-UFD1 antibody

UFD1L Rabbit mAb

Cat. Num. AAA4753089

• Gene Names: UFD1L; UFD1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunocytochemistry, Immunofluorescence, Flow Cytometry, Functional Assay
• Purity: Affinity purified
• Synonyms: UFD1L; Monoclonal Antibody; UFD1L Rabbit mAb; Ubiquitin recognition factor in ER-associated degradation protein 1; anti-UFD1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Monoclonal
• Isotype: Rabbit IgG
• Clone Number: R09-7G5
• Specificity: Found in adult heart, skeletal muscle and pancreas, and in fetal liver and kidney. Gene expression databases
• Purity/Purification: Affinity purified
• Form/Format: Supplied in 50nM Tris-Glycine (pH7.4), 0.15M Nacl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

• Applicable Applications for anti-UFD1 antibody: Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FC/FACS)
• Application Notes: WB: 1:1000-1:5000; ICC/IF: 1:20; FC/FACS: 1:20
• Immunogen: A synthetic peptide of human UFD1L
• Conjugation: Unconjugated
• Modification: Unmodification
• Subcellular Location: Cytoplasm, Nucleus
• Preparation and Storage: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze/thaw cycle.

Western Blot (WB)

(Western blot detection of UFD1L in Hela cell lysates using UFD1L Rabbit mAb(1:1000 diluted). Predicted band size:35kDa. Observed band size:40kDa.)

Related Product Information for anti-UFD1 antibody

The protein encoded by this gene forms a complex with two other proteins, nuclear protein localization-4 and valosin-containing protein, and this complex is necessary for the degradation of ubiquitinated proteins. In addition, this complex controls the disassembly of the mitotic spindle and the formation of a closed nuclear envelope after mitosis. Mutations in this gene have been associated with Catch 22 syndrome as well as cardiac and craniofacial defects. Alternative splicing results in multiple transcript variants encoding different isoforms. A related pseudogene has been identified on chromosome 18. [provided by RefSeq, Jun 2009]
Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures. Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729).

NCBI and Uniprot Product Information

• NCBI GI #: 241982785
• NCBI GeneID: 7353
• NCBI Accession #: NP_001030324.2
• NCBI GenBank Nucleotide #: NM_001035247.2
• UniProt Accession #: Q92890; Q9Y5N0; A8MW31
• Molecular Weight: 307
• NCBI Official Full Name: ubiquitin fusion degradation protein 1 homolog isoform B
• NCBI Official Synonym Full Names: ubiquitin fusion degradation 1 like (yeast)
• NCBI Official Symbol: UFD1L
• NCBI Official Synonym Symbols: UFD1
• NCBI Protein Information: ubiquitin fusion degradation protein 1 homolog; UB fusion protein 1
• UniProt Protein Name: Ubiquitin fusion degradation protein 1 homolog
• Protein Family: Ubiquitin fusion degradation protein
• UniProt Gene Name: UFD1L
• UniProt Synonym Gene Names: UB fusion protein 1
• UniProt Entry Name: UFD1_HUMAN