E3 ubiquitin-protein ligase UBR5 (Ubr5) Recombinant Protein | Ubr5 recombinant protein

Recombinant Rat E3 ubiquitin-protein ligase UBR5 (Ubr5) , partial

• Gene Names: Ubr5; Dd5; Rat100
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: E3 ubiquitin-protein ligase UBR5 (Ubr5); Recombinant Rat E3 ubiquitin-protein ligase UBR5 (Ubr5); partial; Ubr5 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 2788

• Species: Rat
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Ubr5 recombinant protein

This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation.

NCBI and Uniprot Product Information

• NCBI GI #: 378405229
• NCBI GeneID: 117060
• UniProt Accession #: Q62671; F1LRS0
• Molecular Weight: 308,027 Da
• NCBI Official Full Name: E3 ubiquitin-protein ligase UBR5
• NCBI Official Synonym Full Names: ubiquitin protein ligase E3 component n-recognin 5
• NCBI Official Symbol: Ubr5
• NCBI Official Synonym Symbols: Dd5; Rat100
• NCBI Protein Information: E3 ubiquitin-protein ligase UBR5
• UniProt Protein Name: E3 ubiquitin-protein ligase UBR5
• Protein Family: E3 ubiquitin-protein ligase
• UniProt Gene Name: Ubr5
• UniProt Synonym Gene Names: Dd5; Edd; Edd1; Hyd

NCBI Description

may be involved in sexual maturation [RGD, Feb 2006]

Uniprot Description

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) for the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes ().