Sts1 Blocking Peptide | UBASH3B blocking peptide

Sts1 Blocking Peptide

Cat. Num. AAA9622412

• Gene Names: UBASH3B; p70; STS1; STS-1; TULA2; TULA-2
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: Sts1; Sts1 Blocking Peptide; Cbl interacting protein p70; Cbl interacting protein Sts 1; Cbl interacting protein Sts1; Cbl-interacting protein p70; KIAA1959; MGC15437; Nm23 phosphorylated unknown substrate; p70; SH3 domain containing 70 kDa protein; Sts 1; STS-1; STS1; Suppressor of T cell receptor signaling 1; Suppressor of T-cell receptor signaling 1; T-cell ubiquitin ligand 2; TULA-2; Tyrosine-protein phosphatase STS1/TULA2; Ubash3b; Ubiquitin associated and SH3 domain containing B; Ubiquitin-associated and SH3 domain-containing protein B; UBS3B_HUMAN; UBASH3B blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for UBASH3B blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for UBASH3B blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 110287974
• NCBI GeneID: 84959
• UniProt Accession #: Q8TF42; Q53GT5; Q53GT8; Q8NBV7; Q96IG9; Q96NZ2
• Molecular Weight: 649
• NCBI Official Full Name: Ubiquitin-associated and SH3 domain-containing protein B
• NCBI Official Synonym Full Names: ubiquitin associated and SH3 domain containing B
• NCBI Official Symbol: UBASH3B
• NCBI Official Synonym Symbols: p70; STS1; STS-1; TULA2; TULA-2
• NCBI Protein Information: ubiquitin-associated and SH3 domain-containing protein B; T-cell ubiquitin ligand 2; cbl-interacting protein p70; Cbl-interacting protein Sts-1; nm23-phosphorylated unknown substrate; tyrosine-protein phosphatase STS1/TULA2; suppressor of T-cell receptor
• UniProt Protein Name: Ubiquitin-associated and SH3 domain-containing protein B
• Protein Family: STS14 protein
• UniProt Gene Name: UBASH3B
• UniProt Synonym Gene Names: KIAA1959; STS1; STS-1; TULA-2
• UniProt Entry Name: UBS3B_HUMAN

NCBI Description

This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. [provided by RefSeq, Jul 2008]

Uniprot Description

STS-1: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.

Protein type: EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor)

Chromosomal Location of Human Ortholog: 11q24.1

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding; protein tyrosine phosphatase activity

Biological Process: negative regulation of protein kinase activity; regulation of release of sequestered calcium ion into cytosol