Rat ubiquitin-like modifier activating enzyme 3 ELISA Kit | UBA3 elisa kit
Rat NEDD8-activating enzyme E1 Catalytic subunit, UBA3 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
catalytic subunit of the activating enzyme of the ubiquitin-like NEDD8 conjugation pathway (known as neddylation); inhibits transcription induced by steroid hormone receptors [RGD, Feb 2006]
Uniprot Description
UBA3: Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression. Belongs to the ubiquitin-activating E1 family. UBA3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation; Nuclear receptor co-regulator; Ubiquitin conjugating system; EC 6.3.2.19; Ligase; EC 6.3.2.-; Ubiquitin ligase
Cellular Component: cytosol; nucleus
Molecular Function: ligand-dependent nuclear receptor binding; NEDD8 activating enzyme activity; acid-amino acid ligase activity; small protein activating enzyme activity; protein heterodimerization activity; ATP binding
Biological Process: protein neddylation; regulation of cell cycle; mitotic cell cycle; endomitotic cell cycle; negative regulation of transcription, DNA-dependent
Research Articles on UBA3
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Product Notes
The Rat UBA3 uba3 (Catalog #AAA9333302) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9333302 ELISA Kit recognizes Rat UBA3. It is sometimes possible for the material contained within the vial of "ubiquitin-like modifier activating enzyme 3, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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