Typical Testing Data/Standard Curve (for reference only)
Rat NEDD8-activating enzyme E1 catalytic subunit ELISA Kit | Uba3 elisa kit
Rat NEDD8-activating enzyme E1 catalytic subunit ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
NCBI Description
catalytic subunit of the activating enzyme of the ubiquitin-like NEDD8 conjugation pathway (known as neddylation); inhibits transcription induced by steroid hormone receptors [RGD, Feb 2006]
Uniprot Description
UBA3: Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression. Belongs to the ubiquitin-activating E1 family. UBA3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear receptor co-regulator; Ligase; EC 6.3.2.19; Ubiquitin ligase; Cell cycle regulation; Ubiquitin conjugating system; EC 6.3.2.-
Cellular Component: cytosol; nucleus
Molecular Function: acid-amino acid ligase activity; ATP binding; ligand-dependent nuclear receptor binding; NEDD8 activating enzyme activity; protein heterodimerization activity
Biological Process: endomitotic cell cycle; mitotic cell cycle; negative regulation of transcription, DNA-dependent; protein neddylation; regulation of cell cycle
Research Articles on Uba3
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Product Notes
The Rat Uba3 uba3 (Catalog #AAA2886414) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2886414 ELISA Kit recognizes Rat Uba3. It is sometimes possible for the material contained within the vial of "NEDD8-activating enzyme E1 catalytic subunit, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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