Thioredoxin Reductase 2 Recombinant Protein | TXNRD3 recombinant protein

Thioredoxin Reductase 2 protein

• Gene Names: TXNRD3; TGR; TR2; TRXR3
• Applications: Western Blot
• Purity: > 95% pure
• Synonyms: Thioredoxin Reductase 2; Thioredoxin Reductase 2 protein; tr protein; tr2 protein; tr 2 protein; trxr protein; Thioredoxin (TrxR) Reductase protein; EC 1.8.1.9 protein; Gene associated with retinoid IFN induced mortality 12 protein protein; GRIM 12 protein; KM 102 derived reductase like factor protein; MGC9145 protein; Selenoprotein Z protein; SELZ protein; TGR protein; Thioredoxin and glutathione reductase protein; Thioredoxin glutathione reductase protein; Thioredoxin reductase 1 protein; Thioredoxin reductase 2 protein; Thioredoxin reductase 3 protein; Thioredoxin reductase beta protein; Thioredoxin reductase GRIM 12 protein; TR protein; TR beta protein; TR1 protein; TR2 protein; TR3 protein; TrxR protein; TRXR1 protein; TRXR2 protein; TRXR3 protein; TXNR protein; TXNRD1 protein; TXNRD2 protein; TXNRD3 protein; TXNRD3 recombinant protein

• Host: Human
• Purity/Purification: > 95% pure
• Form/Format: Supplied in lyophilized form from 20mM HEPES, pH 7.4
• Sequence Length: 607

• Applicable Applications for TXNRD3 recombinant protein: Western Blot (WB)
• Protein Type: Recombinant
• Biological Significance: Thioredoxin Reductase 2 maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox-regulated cell signaling.
• Expression System: E Coli
• Preparation and Storage: Store at -20 degree C. After reconstitution store at -80 degree C. Avoid frequent freeze/thaw cycles

Western Blot (WB)

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Related Product Information for TXNRD3 recombinant protein

Purified recombinant Thioredoxin Reductase 2 protein

Product Categories/Family for TXNRD3 recombinant protein

Proteases; Inhibitors; & Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 291045268
• NCBI GeneID: 114112
• NCBI Accession #: NP_001166984.1
• NCBI GenBank Nucleotide #: NM_001173513.1
• Molecular Weight: 55.4 kDa
• NCBI Official Full Name: thioredoxin reductase 3 isoform 2
• NCBI Official Synonym Full Names: thioredoxin reductase 3
• NCBI Official Symbol: TXNRD3
• NCBI Official Synonym Symbols: TGR; TR2; TRXR3
• NCBI Protein Information: thioredoxin reductase 3
• UniProt Protein Name: Thioredoxin reductase 3
• Protein Family: Thioredoxin reductase
• UniProt Gene Name: TXNRD3
• UniProt Entry Name: TRXR3_HUMAN

NCBI Description

This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein catalyzes the reduction of thioredoxin, and is implicated in the defense against oxidative stress. It contains a selenocysteine (Sec) residue (which is essential for catalytic activity), encoded by a UGA codon, at the penultimate C-terminal position. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Uniprot Description

TXNRD3: Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Protein type: Oxidoreductase; EC 1.8.1.9

Chromosomal Location of Human Ortholog: 3q21.3

Cellular Component: endoplasmic reticulum; nucleus

Molecular Function: thioredoxin-disulfide reductase activity; electron carrier activity; FAD binding; protein disulfide oxidoreductase activity

Biological Process: cell redox homeostasis; multicellular organismal development; spermatogenesis; cell differentiation