SDS-PAGE
(10% SDS-PAGE Coomassie staining. Lane 1: 1ug A20. Lane 2: Protein Marker. MW: 90kD. Purity: ~10%)
Tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) Recombinant Protein | TNFAIP3 recombinant protein
TNFAIP3, Recombinant, Human, DYKDDDDK-Tag
Purity
Purified (~10%)
Synonyms
Tumor necrosis factor; alpha-induced protein 3 (TNFAIP3); TNFAIP3; Recombinant; Human; DYKDDDDK-Tag; Tumor Necrosis FactorAlpha-induced Protein 3; TNF Alpha-induced Protein 3; OTUDomain-containing Protein 7C; Putative DNA-binding Protein A20; ZincFinger Protein A20; OTUD7C; TNFAIP3 recombinant protein
Host
Sf9 Insect Cells
Purity/Purification
Purified (~10%)
Form/Format
Supplied as a liquid in 40mM Tris-HCl, pH 8.0,110mM sodium chloride, 2.2mM potassium chloride,0.05% Tween-20, 80ug/ml DYKDDDDK peptide, 20% glycerol,3mM DTT.
Application Notes
Suitable for for the study of enzyme kinetics, screeninginhibitors, and selectivity profiling. Other applications nottested.
Source Note
Recombinant corresponding to aa2-791 from human TNFAIP3, fused to DYKDDDDK-tag at N-terminal, expressed in Sf9 insect cells via a baculovirus expression system.
Preparation and Storage
Aliquot to avoid repeated freezing and thawing and storeat -70 degree C. Aliquots are stable for 6 months. For maximumrecovery of product, centrifuge the original vial afterthawing and prior to removing the cap.
SDS-PAGE
(10% SDS-PAGE Coomassie staining. Lane 1: 1ug A20. Lane 2: Protein Marker. MW: 90kD. Purity: ~10%)
SDS-PAGE
(10% SDS-PAGE Coomassie staining. Lane 1: 1ug A20. Lane 2: Protein Marker. MW: 90kD. Purity: ~10%)
Test Data
Test Data
Related Product Information for TNFAIP3 recombinant protein
Tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) is a de-ubiquitinating enzyme that containsan N- terminal catalytic domain belonging to theovarian-tumor superfamily of cysteine proteases.TNFAIP3 suppresses apoptosis.It is expressed in variouscell types in response to a variety of stimuli that activatethe transcription factor NF- kB, including Il-1, CD40ligand, and PMA. TNFAIP3 has been stronglysuggested as a key protein involved in tamoxifenresistance, and thus represents both a new breast cancermarker and a promising target for developing newstrategies to prevent the emergence of acquiredmechanisms of drug resistance in breast cancer.
References
1. Evans P.C., et al. Biochem. J. 378:727-734, 2004
2. Vendrell JA, et al. Oncogene 26(32):4656-67, 2007
3. Daniel S., et al. Blood104(8):2376-84,2004.
4 Shi CS, Kehrl JH. (2010). Autophagy 6(7):986-7.
5. Tavares, R.M., et al. (2010). Immunity 33(2):181-9.
6. Hymowitz,S.G., Wertz, I.E. (2010). Nat. Rev. Cancer 10(5):332-41.
2. Vendrell JA, et al. Oncogene 26(32):4656-67, 2007
3. Daniel S., et al. Blood104(8):2376-84,2004.
4 Shi CS, Kehrl JH. (2010). Autophagy 6(7):986-7.
5. Tavares, R.M., et al. (2010). Immunity 33(2):181-9.
6. Hymowitz,S.G., Wertz, I.E. (2010). Nat. Rev. Cancer 10(5):332-41.
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Product Notes
The TNFAIP3 (Catalog #AAA6120668) is a Recombinant Protein produced from Sf9 Insect Cells and is intended for research purposes only. The product is available for immediate purchase. Suitable for for the study of enzyme kinetics, screeninginhibitors, and selectivity profiling. Other applications nottested. Researchers should empirically determine the suitability of the TNFAIP3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Tumor necrosis factor, alpha-induced protein 3 (TNFAIP3), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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