TSC22D1 recombinant protein
Recombinant Human TSC22D1 Protein (His tag)
Gene Names
TSC22D1; Ptg-2; TSC22; TGFB1I4
Purity
> 92 % as determined by SDS-PAGE
Synonyms
TSC22D1; Recombinant Human TSC22D1 Protein (His tag); hucep-2; DKFZp686O19206; MGC17597; RP11-269C23.2; TGFB1I4; TSC22; TSC22D1 recombinant protein
Host
E Coli
Purity/Purification
> 92 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 7.4
Sequence Length
570
Application Notes
The recombinant human TSC22D1 consisting of 155 amino acids and has a calculated molecular mass of 17.2 kDa. It migrates as an 20 kDa band in SDS-PAGE under reducing conditions as predicted.
Predicted N Terminal
Met
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
Related Product Information for TSC22D1 recombinant protein
Background: TSC22 domain family, member 1 (TSC22D1) is one of the TGF-beta-stimulated clone-22 (TSC-22). TSC-22 was reported to be a differentiation-inducing factor which negatively regulates the growth of salivary gland cancer cells. TSC22D1, which encodes transforming growth factor beta-stimulated clone 22 (TSC-22), is thought to be a tumor suppressor because its expression is lost in many glioblastoma, salivary gland, and prostate cancers. TSC-22 is the founding member of the TSC-22/DIP/Bun family of leucine zipper transcription factors. TSC-22 may play an important role in maintaining the differentiated phenotype in salivary gland tumors, and may be a possible target of leukemia therapy. TSC22D1 forms homodimers via its conserved leucine zipper domain and heterodimerizes with TSC22D4. TSC22D1 has transcriptional repressor activity.
Description: A DNA sequence encoding the human TSC22D1 isoform 2 (Q15714-2) (Met 1-Ala 144) was expressed, with a polyhistidine tag at the N-terminus.
Description: A DNA sequence encoding the human TSC22D1 isoform 2 (Q15714-2) (Met 1-Ala 144) was expressed, with a polyhistidine tag at the N-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
58,859 Da
NCBI Official Full Name
TSC22 domain family protein 1 isoform 4
NCBI Official Synonym Full Names
TSC22 domain family member 1
NCBI Official Symbol
TSC22D1
NCBI Official Synonym Symbols
Ptg-2; TSC22; TGFB1I4
NCBI Protein Information
TSC22 domain family protein 1
UniProt Protein Name
TSC22 domain family protein 1
Protein Family
UniProt Gene Name
TSC22D1
UniProt Synonym Gene Names
KIAA1994; TGFB1I4; TSC22
NCBI Description
This gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
Uniprot Description
Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter.
Research Articles on TSC22D1
1. TSC-22 acts as a tumor suppressor by safeguarding p53 from poly-ubiquitination mediated-degradation.
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Product Notes
The TSC22D1 tsc22d1 (Catalog #AAA2545460) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The recombinant human TSC22D1 consisting of 155 amino acids and has a calculated molecular mass of 17.2 kDa. It migrates as an 20 kDa band in SDS-PAGE under reducing conditions as predicted. Researchers should empirically determine the suitability of the TSC22D1 tsc22d1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TSC22D1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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