Transient receptor potential cation channel subfamily V member 1 (Trpv1) Recombinant Protein | Trpv1 recombinant protein

Recombinant Guinea pig Transient receptor potential cation channel subfamily V member 1 (Trpv1), partial

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Transient receptor potential cation channel subfamily V member 1 (Trpv1); Recombinant Guinea pig Transient receptor potential cation channel subfamily V member 1 (Trpv1); partial; Trpv1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 839

• Species: Cavia porcellus (Guinea pig)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 289547618
• NCBI GeneID: 100135466
• NCBI Accession #: NP_001166123.1
• NCBI GenBank Nucleotide #: NM_001172652.1
• UniProt Accession #: Q6R5A3; Q8K1W1
• Molecular Weight: 95,244 Da
• NCBI Official Full Name: transient receptor potential cation channel subfamily V member 1
• NCBI Official Symbol: Trpv1
• NCBI Protein Information: transient receptor potential cation channel subfamily V member 1
• UniProt Protein Name: Transient receptor potential cation channel subfamily V member 1
• Protein Family: Transient receptor potential cation channel subfamily
• UniProt Gene Name: Trpv1
• UniProt Synonym Gene Names: TrpV1; OTRPC1

Uniprot Description

Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli (PubMed:12243775). Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca2+-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis ().