Rabbit anti-Human LRP3 Polyclonal Antibody | anti-LRP3 antibody

LRP3, CT (Low Density Lipoprotein Receptor-related Protein 3, LRP-3, 105kD Low-density Lipoprotein Receptor-related Protein, hLRp105)

Cat. Num. AAA6000991

• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: LRP3; Polyclonal Antibody; CT (Low Density Lipoprotein Receptor-related Protein 3; LRP-3; 105kD Low-density Lipoprotein Receptor-related Protein; hLRp105); Anti -LRP3; anti-LRP3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human LRP3.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.1% sodium azide.

• Applicable Applications for anti-LRP3 antibody: ELISA (EL/EIA), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA and Immunohistochemistry.; Dilution: ELISA: 1:1000; Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml
• Immunogen: Synthetic peptide corresponding to aa676-693 of human LRP3 (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Human Skin (formalin-fixed, paraffin-embedded) stained with LRP3 antibody at 10ug/ml followed by biotinylated goat rabbit IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.)

Related Product Information for anti-LRP3 antibody

Low density lipoprotein (LDL) receptor-related protein (LRP), a member of the LDL receptor family, binds multiple classes of ligands and has been implicated in a broad range of normal and disease processes involving lipid metabolism, protease clearance, and cell migration. Structurally, members of the LDLR family share homology within their extracellular domains, which are highlighted by the presence of clusters of ligand-binding repeats. LRP is a large endocytic receptor that participates in several biological pathways and plays prominent roles in lipoprotein metabolism and in the catabolism of proteinases involved in coagulation and fibrinolysis. LRP also mediates the cellular entry of certain viruses and toxins and facilitates the activation of various lysosomal enzymes. All LRPs are expressed in the central nervous system and, for most receptors, animal models have shown that they are indispensable for successful neurodevelopment. The mechanisms by which they regulate the formation of the nervous system are varied and include the transduction of extracellular signals and the modulation of intracellular signal propagation, as well as cargo transport, the function most commonly attributed to this gene family.

Product Categories/Family for anti-LRP3 antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 167555125
• NCBI GeneID: 4037
• NCBI Accession #: NP_002324.2
• NCBI GenBank Nucleotide #: NM_002333.3
• UniProt Accession #: O75074; B3KQD6; B4DKF2
• Molecular Weight: 82,884 Da
• NCBI Official Full Name: low-density lipoprotein receptor-related protein 3
• NCBI Official Synonym Full Names: low density lipoprotein receptor-related protein 3
• NCBI Official Symbol: LRP3
• NCBI Protein Information: low-density lipoprotein receptor-related protein 3; LRP-3; hLRp105; 105 kDa low-density lipoprotein receptor-related protein
• UniProt Protein Name: Low-density lipoprotein receptor-related protein 3
• Protein Family: Low-density lipoprotein receptor-related protein
• UniProt Gene Name: LRP3
• UniProt Synonym Gene Names: LRP-3; hLRp105
• UniProt Entry Name: LRP3_HUMAN

Uniprot Description

LRP3: Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro. Belongs to the LDLR family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.11

Cellular Component: integral to membrane; coated pit

Biological Process: receptor-mediated endocytosis